1-(7-Methoxy-3,6-dimethyl-3,4-dihydro-naphthalen-2-yl)-pyrrolidine | 208396-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(7-Methoxy-3,6-dimethyl-3,4-dihydro-naphthalen-2-yl)-pyrrolidine
• 英文别名: 1-(7-Methoxy-3,6-dimethyl-3,4-dihydronaphthalen-2-yl)pyrrolidine
• CAS: 208396-29-6
• 化学式: C₁₇H₂₃NO
• 分子量: 257.376
• InChiKey: YXPZWIDCYRXACJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  丙烯醛 、 1-(7-Methoxy-3,6-dimethyl-3,4-dihydro-naphthalen-2-yl)-pyrrolidine 以 1,4-二氧六环 为溶剂， 反应 12.0h， 生成 4-Methoxy-5,9-dimethyl-10-pyrrolidin-1-yl-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5-trien-13-one
  参考文献：
  名称：

  A Total Synthesis of the Racemic Sesquiterpene Parvifoline

  摘要：

  A total synthesis of the sesquiterpene (+/-)-parvifoline 1 from the symmetrical naphthalene 4 is reported. The key step of the synthesis was a Stork-Landesman two-carbon ring expansion of beta-tetralone 5, which affords 9a with the complete framework of the target. Although many reactions are involved in the sequence, the whole synthesis can be executed in only five synthetic operations and in approximate to 18% overall yield.

  DOI：

  10.1021/jo972092p
• 作为产物：
  描述：

  1,4-dihydro-2,7-dimethoxy-3,6-dimethylnaphthalene 以 苯 为溶剂， 反应 2.25h， 生成 1-(7-Methoxy-3,6-dimethyl-3,4-dihydro-naphthalen-2-yl)-pyrrolidine
  参考文献：
  名称：

  A Total Synthesis of the Racemic Sesquiterpene Parvifoline

  摘要：

  A total synthesis of the sesquiterpene (+/-)-parvifoline 1 from the symmetrical naphthalene 4 is reported. The key step of the synthesis was a Stork-Landesman two-carbon ring expansion of beta-tetralone 5, which affords 9a with the complete framework of the target. Although many reactions are involved in the sequence, the whole synthesis can be executed in only five synthetic operations and in approximate to 18% overall yield.

  DOI：

  10.1021/jo972092p

文献信息

• A Total Synthesis of the Racemic Sesquiterpene Parvifoline
  作者：Adrián Covarrubias-Zúñiga、Fernando Cantú、Luis A. Maldonado

  DOI：10.1021/jo972092p

  日期：1998.5.1

  A total synthesis of the sesquiterpene (+/-)-parvifoline 1 from the symmetrical naphthalene 4 is reported. The key step of the synthesis was a Stork-Landesman two-carbon ring expansion of beta-tetralone 5, which affords 9a with the complete framework of the target. Although many reactions are involved in the sequence, the whole synthesis can be executed in only five synthetic operations and in approximate to 18% overall yield.