N2-Fmoc-5'-O-DMT-deoxyguanosine | 109205-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N2-Fmoc-5'-O-DMT-deoxyguanosine
• 英文别名: 9H-fluoren-9-ylmethyl N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]carbamate
• CAS: 109205-69-8
• 化学式: C₄₆H₄₁N₅O₈
• 分子量: 791.86
• InChiKey: BNMBHGYQSUDIRK-KQIHHXPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  59
• 可旋转键数：
  13
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  155
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N2-Fmoc-5'-O-DMT-deoxyguanosine 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N-2-Fmoc-5'-0-DMT-2'-deoxyguanosine-3'-cyanoethyl phosphoramidite
  参考文献：
  名称：

  The 9-Fluorenylmethoxycarbonyl (Fmoc) Group and Its Use in Oligonucleotide Synthesis

  摘要：

  The introduction of the base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group into the exocyclic amino function of 2'-deoxynucleosides and their dimethoxytritylation and phosphitylation is described. The resulting key intermediates were investigated in the built-up of different oligodeoxyribonucleoside phosphate and thiophosphate chains which were deprotected under mild basic conditions leading to crude oligomers of high purity.

  DOI：

  10.1080/07328319908044667
• 作为产物：
  描述：

  2'-deoxy-N²-<(9H-fluoren-9-ylmethoxy)carbonyl>guanosine 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N2-Fmoc-5'-O-DMT-deoxyguanosine
  参考文献：
  名称：

  The 9-Fluorenylmethoxycarbonyl (Fmoc) Group and Its Use in Oligonucleotide Synthesis

  摘要：

  The introduction of the base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group into the exocyclic amino function of 2'-deoxynucleosides and their dimethoxytritylation and phosphitylation is described. The resulting key intermediates were investigated in the built-up of different oligodeoxyribonucleoside phosphate and thiophosphate chains which were deprotected under mild basic conditions leading to crude oligomers of high purity.

  DOI：

  10.1080/07328319908044667

文献信息

• Aminoacylation of Nucleosides with FMOC Amino Acid Fluorides¹
  作者：J. S. Oliver、A. Oyelere

  DOI：10.1021/jo9601674

  日期：1996.1.1
• [EN] N-FMOC NUCLEOSIDES AND PHOSPHORAMIDITES, AND OLIGONUCLEOTIDE SYNTHESIS<br/>[FR] NUCLÉOSIDES ET PHOSPHORAMIDITES N-FMOC ET SYNTHÈSE D'OLIGONUCLÉOTIDES
  申请人：CHEMGENES CORP

  公开号：WO2010062404A3

  公开（公告）日：2010-10-14
• The 9-Fluorenylmethoxycarbonyl (Fmoc) Group and Its Use in Oligonucleotide Synthesis
  作者：H. Schirmeister-tichy、G. G. Alvarado、W. Pfleiderer

  DOI：10.1080/07328319908044667

  日期：1999.6

  The introduction of the base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group into the exocyclic amino function of 2'-deoxynucleosides and their dimethoxytritylation and phosphitylation is described. The resulting key intermediates were investigated in the built-up of different oligodeoxyribonucleoside phosphate and thiophosphate chains which were deprotected under mild basic conditions leading to crude oligomers of high purity.