2-chloro-9H-thioxanthene-9-thione | 17435-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: 2-chloro-9H-thioxanthene-9-thione
• 英文别名: 2-chloro-thioxanthene-9-thione；2-Chlorothioxanthene-9-thione
• CAS: 17435-07-3
• 化学式: C₁₃H₇ClS₂
• 分子量: 262.784
• InChiKey: QRXADHOQUFFZKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-9H-thioxanthene-9-thione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以28.571%的产率得到
  参考文献：
  名称：

  催化剂控制的立体选择性巴顿-凯洛格烯化

  摘要：

  过度拥挤的烯烃可以通过多功能的 Barton-Kellogg 烯化反应快速制备，并且由于其独特的立体化学特征而作为功能分子具有显着的应用。因此，诱导的立体动力学使得分子开关和马达的受控运动成为可能，同时高构型稳定性防止了不需要的异构体加扰。双三环芳香烯是典型的拥挤烯烃，具有出色的立体化学性质，但迄今为止，它们的立体控制制备只能在立体有择反应和手性助剂的情况下进行。在此，我们报道了通过对各种双三环芳族烯进行对映体和非对映体控制的立体选择性巴顿-凯洛格烯化反应来实现直接催化剂控制。使用Rh 2 ( S -PTAD) 4作为催化剂，几种重氮化合物选择性地与硫酮偶联，还原后得到四种反折叠过度拥挤的烯烃立体异构体之一。通过催化剂控制与独特的硫杂丙环还原相结合，实现了完全的立体发散，从而提供了 er 值高达 99:1 的所有四种立体异构体。我们预计，这一策略将能够合成拓扑独特的过度拥挤烯烃，用于功能材

  DOI：

  10.1002/anie.202109519
• 作为产物：
  描述：

  2-氯噻吨酮 在 tetraphosphorus decasulfide 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以70%的产率得到2-chloro-9H-thioxanthene-9-thione
  参考文献：
  名称：

  催化剂控制的立体选择性巴顿-凯洛格烯化

  摘要：

  过度拥挤的烯烃可以通过多功能的 Barton-Kellogg 烯化反应快速制备，并且由于其独特的立体化学特征而作为功能分子具有显着的应用。因此，诱导的立体动力学使得分子开关和马达的受控运动成为可能，同时高构型稳定性防止了不需要的异构体加扰。双三环芳香烯是典型的拥挤烯烃，具有出色的立体化学性质，但迄今为止，它们的立体控制制备只能在立体有择反应和手性助剂的情况下进行。在此，我们报道了通过对各种双三环芳族烯进行对映体和非对映体控制的立体选择性巴顿-凯洛格烯化反应来实现直接催化剂控制。使用Rh 2 ( S -PTAD) 4作为催化剂，几种重氮化合物选择性地与硫酮偶联，还原后得到四种反折叠过度拥挤的烯烃立体异构体之一。通过催化剂控制与独特的硫杂丙环还原相结合，实现了完全的立体发散，从而提供了 er 值高达 99:1 的所有四种立体异构体。我们预计，这一策略将能够合成拓扑独特的过度拥挤烯烃，用于功能材

  DOI：

  10.1002/anie.202109519

文献信息

• Temperature-sensitive nano-carriers
  申请人：Gwangju Institute of Science and Technology

  公开号：EP2082734A2

  公开（公告）日：2009-07-29

  The present invention relates to a process of preparing a biocompatible temperature-sensitive nano-carrier, which comprises the steps of (a) preparing a polymer dispersion comprising a water-soluble biocompatible polymer with photo-crosslinkable functional group(s), (b) preparing a polymer-initiator solution by adding an initiator to the polymer dispersion, and (c) preparing the nano-carrier by irradiating light onto the polymer-initiator solution, wherein the average diameter of the nano-carrier changes depending on temperature, and also relates to a temperature-sensitive nano-carrier. Nano-carriers of the present invention are temperature-sensitive, and their average diameter and pore size reversibly change in response to temperature change. In an embodiment of the present invention, nano-carriers can be prepared via a one-pot single-phase synthesis. A process of the present invention overcomes the conventional problems such as the use of organic solvent, complicated preparation steps, a relatively high manufacture cost and a low loading efficiency. Moreover, a process of the present invention can ensure the stability of drugs without necessitating high-speed homogenization or ultrasonification generally carried out in the conventional process.

  本发明涉及一种制备生物相容性温敏纳米载体的工艺，该工艺包括以下步骤：(a) 制备聚合物分散体，该聚合物分散体由具有光交联官能团的水溶性生物相容性聚合物组成、(b) 通过向聚合物分散体中添加引发剂制备聚合物引发剂溶液，以及 (c) 通过向聚合物引发剂溶液照射光制备纳米载体，其中纳米载体的平均直径随温度变化而变化，这也涉及一种温敏纳米载体。本发明的纳米载体对温度敏感，其平均直径和孔径随温度变化而可逆变化。在本发明的一个实施方案中，纳米载体可通过一锅单相合成法制备。本发明的工艺克服了使用有机溶剂、制备步骤复杂、制造成本相对较高和负载效率较低等传统问题。此外，本发明的工艺还能确保药物的稳定性，而无需进行传统工艺中通常要进行的高速均质或超声波处理。
• TEMPERATURE-SENSITIVE NANO-CARRIERS
  申请人：TAE Gi-yoong

  公开号：US20090196937A1

  公开（公告）日：2009-08-06

  The present invention relates to a process of preparing a biocompatible temperature-sensitive nano-carrier, which comprises the steps of (a) preparing a polymer dispersion comprising a water-soluble biocompatible polymer with photo-crosslinkable functional group(s), (b) preparing a polymer-initiator solution by adding an initiator to the polymer dispersion, and (c) preparing the nano-carrier by irradiating light onto the polymer-initiator solution, wherein the average diameter of the nano-carrier changes depending on temperature, and also relates to a temperature-sensitive nano-carrier. Nano-carriers of the present invention are temperature-sensitive, and their average diameter and pore size reversibly change in response to temperature change. In an embodiment of the present invention, nano-carriers can be prepared via a one-pot single-phase synthesis. A process of the present invention overcomes the conventional problems such as the use of organic solvent, complicated preparation steps, a relatively high manufacture cost and a low loading efficiency. Moreover, a process of the present invention can ensure the stability of drugs without necessitating high-speed homogenization or ultrasonification generally carried out in the conventional process.
• NANOCARRIER HAVING ENHANCED SKIN PERMEABILITY, CELLULAR UPTAKE AND TUMOUR DELIVERY PROPERTIES
  申请人：Tae Gi Yoong

  公开号：US20120087859A1

  公开（公告）日：2012-04-12

  The present invention relates to a biopolymer-modified nanocarrier in which chitosan is bound to a water-soluble biocompatible polymer that has been crosslinked via a photo-crosslinkable functional group; wherein the chitosan-modified nanocarrier has a diameter which changes in accordance with changes in temperature, has enhanced skin permeability or cellular uptake and selective delivery to cancer tissue as compared with a bare nanocarrier to which chitosan has not been bound, and exhibits characteristics that are advantageous in photothermal therapy. The chitosan-modified nanocarrier of the present invention exhibits highly superior efficacy as a transdermal carrier, since the skin permeability is enhanced to a significant level as compared with a bare nanocarrier that has no chitosan. The chitosan-modified nanocarrier of the present invention can be advantageous in the imaging and photothermal therapy of tumour cells and cancer cells, since the cellular uptake by tumour cells and cancer cells is substantially improved.
• US8486528B2
  申请人：——

  公开号：US8486528B2

  公开（公告）日：2013-07-16
• Catalyst‐Controlled Stereoselective Barton–Kellogg Olefination
  作者：Tanno A. Schmidt、Christof Sparr

  DOI：10.1002/anie.202109519

  日期：2021.10.25

  applications as functional molecules owing to their unique stereochemical features. The induced stereodynamics thereby enable the controlled motion of molecular switches and motors, while the high configurational stability prevents undesired isomeric scrambling. Bistricyclic aromatic enes are prototypical overcrowded alkenes with outstanding stereochemical properties, but their stereocontrolled preparation

  过度拥挤的烯烃可以通过多功能的 Barton-Kellogg 烯化反应快速制备，并且由于其独特的立体化学特征而作为功能分子具有显着的应用。因此，诱导的立体动力学使得分子开关和马达的受控运动成为可能，同时高构型稳定性防止了不需要的异构体加扰。双三环芳香烯是典型的拥挤烯烃，具有出色的立体化学性质，但迄今为止，它们的立体控制制备只能在立体有择反应和手性助剂的情况下进行。在此，我们报道了通过对各种双三环芳族烯进行对映体和非对映体控制的立体选择性巴顿-凯洛格烯化反应来实现直接催化剂控制。使用Rh 2 ( S -PTAD) 4作为催化剂，几种重氮化合物选择性地与硫酮偶联，还原后得到四种反折叠过度拥挤的烯烃立体异构体之一。通过催化剂控制与独特的硫杂丙环还原相结合，实现了完全的立体发散，从而提供了 er 值高达 99:1 的所有四种立体异构体。我们预计，这一策略将能够合成拓扑独特的过度拥挤烯烃，用于功能材