N,N-disopropyl-8-hydroxy-2-iodo-1-naphthamide | 714973-90-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-disopropyl-8-hydroxy-2-iodo-1-naphthamide
• CAS: 714973-90-7
• 化学式: C₁₇H₂₀INO₂
• 分子量: 397.256
• InChiKey: NDGQEUZFCFAFFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.41
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  40.54
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N,N-disopropyl-8-hydroxy-2-iodo-1-naphthamide 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 N,N-diisopropyl-2-iodo-8-[(R)-1-(2-naphthyl)ethyl carbamoyl]-1-naphthamide
  参考文献：
  名称：

  Synthesis and properties of atropisomeric phosphinous acids

  摘要：

  In this paper we describe two groups of atropisomeric phosphinous acids-bis-[(N,N-diisopropyl-1-naphthamide)-2-]-phosphinous acids (2 to 4) and their 8-methoxy- substituted relations (8 to 10). The first group of acids interconvert at room temperature and the second group do not. The interconversion and properties are illustrated by two dimensional TLC and some NMR spectra. The peri substituent turns out to be important. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.01.093
• 作为产物：
  描述：

  N,N-disopropyl-8-[tert-butyl(dimethyl)silyloxy]-2-iodo-1-naphthamide 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以100%的产率得到N,N-disopropyl-8-hydroxy-2-iodo-1-naphthamide
  参考文献：
  名称：

  Synthesis and properties of atropisomeric phosphinous acids

  摘要：

  In this paper we describe two groups of atropisomeric phosphinous acids-bis-[(N,N-diisopropyl-1-naphthamide)-2-]-phosphinous acids (2 to 4) and their 8-methoxy- substituted relations (8 to 10). The first group of acids interconvert at room temperature and the second group do not. The interconversion and properties are illustrated by two dimensional TLC and some NMR spectra. The peri substituent turns out to be important. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.01.093