1,4-Bis(5-chloro-2-methoxyphenyl)piperazine-2,5-dione | 1051374-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-Bis(5-chloro-2-methoxyphenyl)piperazine-2,5-dione
• CAS: 1051374-34-5
• 化学式: C₁₈H₁₆Cl₂N₂O₄
• 分子量: 395.242
• InChiKey: KNWDTMJWDNEWOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-n-(5-氯-2-甲氧基苯基)乙酰胺 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 生成 1,4-Bis(5-chloro-2-methoxyphenyl)piperazine-2,5-dione
  参考文献：
  名称：

  The cytotoxic effects of diketopiperaizes against Leishmania donovani promastigotes and amastigotes

  摘要：

  A series of diketopiperazine derivatives (1-12) were evaluated for their in vitro cytotoxic activity against Leishmania donovani promastigotes and amastigotes. Cytotoxicity study revealed that the number and types of the substituents in the phenyl rings have valuable influence on cytotoxic activity. Compounds 1, 3, 4, 11, and 12 demonstrated appreciable cytotoxic activities with the mean IC50 values 1.4, 1.1, 1.02, 1, 0.7 mu g/ml on extra cellular promastigotes and 1.6, 1.8, 0.61, 0.53, 1.1 mu g/ml on intracellular amastigotes, respectively. The results suggested that diketopiperazine derivatives 4, 11, and 12 could be envisaged as new entrants in the domain of antileishmanial agents.

  DOI：

  10.1007/s00044-012-0355-9

文献信息

• The cytotoxic effects of diketopiperaizes against Leishmania donovani promastigotes and amastigotes
  作者：Arindam Maity、Abhijit Hazra、Partha Palit、Shymal Mondal、Sanchaita Lala、Nirup B. Mondal

  DOI：10.1007/s00044-012-0355-9

  日期：2013.7

  A series of diketopiperazine derivatives (1-12) were evaluated for their in vitro cytotoxic activity against Leishmania donovani promastigotes and amastigotes. Cytotoxicity study revealed that the number and types of the substituents in the phenyl rings have valuable influence on cytotoxic activity. Compounds 1, 3, 4, 11, and 12 demonstrated appreciable cytotoxic activities with the mean IC50 values 1.4, 1.1, 1.02, 1, 0.7 mu g/ml on extra cellular promastigotes and 1.6, 1.8, 0.61, 0.53, 1.1 mu g/ml on intracellular amastigotes, respectively. The results suggested that diketopiperazine derivatives 4, 11, and 12 could be envisaged as new entrants in the domain of antileishmanial agents.