4-methoxy-3-methylcinnoline | 5265-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-methoxy-3-methylcinnoline
• 英文别名: 4-Methoxy-3-methyl-cinnolin
• CAS: 5265-27-0
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: ALEGAMQTVZUQEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基噌啉 、 碘甲烷 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以34%的产率得到4-methoxy-3-methylcinnoline
  参考文献：
  名称：

  Metallation of diazines XIV. First O-directed metallation of cinnolines. Metallation of 3-, 4-chloro and 3-, 4-methoxycinnolines

  摘要：

  The lithiation of 3-, 4-chloro and 3-, 4-methoxycinnolines was studied and good yields were obtained. When iodine was used as electrophile, 4,8-diiodo or 4,8-iodochloro compounds were prepared. A xanthone and diazepines were synthetized.

  DOI：

  10.1016/0040-4020(95)00835-v

文献信息

• Metallation of diazines XIV. First O-directed metallation of cinnolines. Metallation of 3-, 4-chloro and 3-, 4-methoxycinnolines
  作者：A. Turck、N. Pié、V. Tallon、G. Quéguiner

  DOI：10.1016/0040-4020(95)00835-v

  日期：1995.11

  The lithiation of 3-, 4-chloro and 3-, 4-methoxycinnolines was studied and good yields were obtained. When iodine was used as electrophile, 4,8-diiodo or 4,8-iodochloro compounds were prepared. A xanthone and diazepines were synthetized.