1-(6-methoxyacenaphthen-5-yl)ethanone | 1241980-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(6-methoxyacenaphthen-5-yl)ethanone
• 英文别名: 1-(6-Methoxyacenaphthen-5-yl)ethanone；1-(6-methoxy-1,2-dihydroacenaphthylen-5-yl)ethanone
• CAS: 1241980-83-5
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: QUAHBRAGZMJNSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(6-methoxyacenaphthen-5-yl)ethanone 、 对甲基苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以71%的产率得到(2E)-1-(6-hydroxyacenaphthen-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  peri-hydroxy acenaphthoyl compounds

  摘要：

  Reactions of peri-hydroxyacenaphthaldehyde and its O-methyl derivative with amines, aryl methyl ketones, and malononitrile gave the corresponding Schiff bases, chalcones, and arylidenemalononitrile. The latter underwent heterocyclization on heating in trifluoroacetic acid to produce 2-oxoacenaphtho[5,6-bc]-oxepine-3-carbonitrile. The condensation of 5-acetyl-6-hydroxyacenaphthene with aromatic aldehydes afforded chalcones, their mixtures with heterocyclization products, or 2-arylacenaphtho[5,6-bc]oxepin-4-one, depending on the substituent in the aromatic ring.

  DOI：

  10.1134/s1070428010030061
• 作为产物：
  描述：

  5-acetyl-6-hydroxyacenaphthene 、 碘甲烷 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 以43%的产率得到1-(6-methoxyacenaphthen-5-yl)ethanone
  参考文献：
  名称：

  Structure of peri-hydroxy- and peri-methoxy-substituted aldehydes and ketones according to spectral data and quantum-chemical calculations

  摘要：

  The structure of peri-hydroxy- and peri-methoxy-substituted aldehydes and ketones of the naphthalene, acenaphthene, and acenaphthylene series and the nature of intramolecular interactions between the peri-substituents therein were determined by spectral (IR, UV, 1H NMR), X-ray diffraction, and quantum-chemical methods.

  DOI：

  10.1134/s1070428010010094

文献信息

• Structure of peri-hydroxy- and peri-methoxy-substituted aldehydes and ketones according to spectral data and quantum-chemical calculations
  作者：V. V. Mezheritskii、A. N. Bezuglov、L. G. Minyaeva、K. A. Lysenko、Yu. V. Revinskii、A. A. Milov

  DOI：10.1134/s1070428010010094

  日期：2010.1

  The structure of peri-hydroxy- and peri-methoxy-substituted aldehydes and ketones of the naphthalene, acenaphthene, and acenaphthylene series and the nature of intramolecular interactions between the peri-substituents therein were determined by spectral (IR, UV, 1H NMR), X-ray diffraction, and quantum-chemical methods.
• peri-hydroxy acenaphthoyl compounds
  作者：A. N. Bezuglov、L. G. Minyaeva、K. A. Lysenko、V. V. Mezheritskii

  DOI：10.1134/s1070428010030061

  日期：2010.3

  Reactions of peri-hydroxyacenaphthaldehyde and its O-methyl derivative with amines, aryl methyl ketones, and malononitrile gave the corresponding Schiff bases, chalcones, and arylidenemalononitrile. The latter underwent heterocyclization on heating in trifluoroacetic acid to produce 2-oxoacenaphtho[5,6-bc]-oxepine-3-carbonitrile. The condensation of 5-acetyl-6-hydroxyacenaphthene with aromatic aldehydes afforded chalcones, their mixtures with heterocyclization products, or 2-arylacenaphtho[5,6-bc]oxepin-4-one, depending on the substituent in the aromatic ring.