N-(2-氨基-2-苯基乙基)-N,N-二乙胺 | 31788-87-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-氨基-2-苯基乙基)-N,N-二乙胺
• 英文名称: N²,N²-diethyl-1-phenyl-1,2-ethanediamine
• 英文别名: 1-(2'-Phenyl-2'-amino-ethyl)-t-diethylamin；N-(2-amino-2-phenylethyl)-N,N-diethylamine；N',N'-diethyl-1-phenylethane-1,2-diamine
• CAS: 31788-87-1
• 化学式: C₁₂H₂₀N₂
• mdl: MFCD06655367
• 分子量: 192.304
• InChiKey: XEIFQVOOARCSSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2921590090

反应信息

• 作为反应物：
  描述：

  N-(2-氨基-2-苯基乙基)-N,N-二乙胺 生成 N-<2-(diethylamino)-1-phenylethyl>-4-<(methylsulfonyl)amino>benzamide hydrochloride
  参考文献：
  名称：

  N-(aminoalkyl)-substituted(N or C

  摘要：

  公式为##STR1##的N-(氨基烷基)-取代(N或C烷基)-芳基-4-(甲基磺酰氨基)苯甲酰胺，其中R为C.sub.1-C.sub.4直链烷基，R.sub.1、R.sub.2和R.sub.3中的一个为苯基或萘基，其余为氢，--NR.sub.4 R.sub.5为二级或三级氨基基团，X和X.sub.1为氢或烷基，n为0或1，可用于治疗心律失常，特别是作为I类/III类联合药物。

  公开号：

  US04920116A1

文献信息

• METHOD FOR PRODUCING OPTICALLY ACTIVE ISOPULEGOL AND OPTICALLY ACTIVE MENTHOL
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150329452A1

  公开（公告）日：2015-11-19

  A method for producing an optically active isopulegol includes asymmetrically isomerizing a specific compound in the presence of a ruthenium catalyst and a base, thereby giving an optically active citronellal, and selectively cyclizing the optically active citronellal in the presence of an aluminum catalyst. The aluminum catalyst is obtained by reacting a specific hydroxy compound and at least one aluminum compound selected from a specific alkylaluminum compound, a specific hydride aluminum compound, a specific linear aluminoxane and a specific cyclic aluminoxane.

  一种制备光学活性异莪醇的方法包括在钌催化剂和碱的存在下不对称异构化特定化合物，从而得到光学活性柠檬醛，并在铝催化剂的存在下选择性地环化光学活性柠檬醛。铝催化剂通过将特定的羟基化合物和至少一种铝化合物（从特定的烷基铝化合物、特定的氢化铝化合物、特定的线性铝氧烷和特定的环状铝氧烷中选择）反应而得到。
• METHOD OF PRODUCING OPTICALLY-ACTIVE ALDEHYDE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150376102A1

  公开（公告）日：2015-12-31

  A method for producing, in a few simple steps, a specific optically active aldehyde represented by the general formula (1), in which * is an asymmetric carbon atom, includes asymmetrically isomerizing a specific allyl alcohol represented by the general formula (2) in the presence of a ruthenium complex and a base.

  一种用几个简单步骤制备特定光学活性醛的方法，该醛由通式（1）表示，其中 * 是不对称碳原子，包括在钌配合物和碱存在下，不对称地异构化由通式（2）表示的特定烯丙醇。
• Method of producing optically-active aldehyde
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US10029969B2

  公开（公告）日：2018-07-24

  A method for producing, in a few simple steps, a specific optically active aldehyde represented by the general formula (1), in which * is an asymmetric carbon atom, includes asymmetrically isomerizing a specific allyl alcohol represented by the general formula (2) in the presence of a ruthenium complex and a base.

  一种通过几个简单步骤生产通式（1）表示的特定光学活性醛（其中 * 为不对称碳原子）的方法，包括在钌络合物和碱存在下，对通式（2）表示的特定烯丙基醇进行不对称异构化。
• Method for producing alcohols
  申请人：Takasago International Corporation

  公开号：EP1970360B1

  公开（公告）日：2016-08-31
• Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents
  作者：Gary B. Phillips、Thomas K. Morgan、Klaus Nickisch、Joan M. Lind、Robert P. Gomez、Ronald A. Wohl、Thomas M. Argentieri、Mark E. Sullivan

  DOI：10.1021/jm00164a025

  日期：1990.2

  Twelve novel derivatives of the selective class III antiarrhythmic agent sematilide were prepared in an attempt to incorporate both class I and class III electrophysiological properties into a single molecule. Electrophysiological activity was determined by standard microelectrode techniques in canine cardiac Purkinje fibers. Initial assessment of class I efficacy was carried out in a ouabain-induced arrhythmia model in guinea pigs. All of the compounds prolonged action potential duration in Purkinje fibers (class III activity), and three were active against ouabain-induced arrhythmias (class I activity). Selected compounds were evaluated further in dogs for efficacy against arrhythmias occurring 24 h following coronary ligation (automatic arrhythmias) and induced by using programmed electrical stimulation techniques (reentrant arrhythmias). The most effective compounds from the series are 3g and -j, which were effective in both canine models. Molecular modeling and structure-activity relationships are discussed.