(R)-1-diethylamino-2-propanethiol | 119353-41-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-1-diethylamino-2-propanethiol
• 英文别名: (2R)-1-(diethylamino)propane-2-thiol
• CAS: 119353-41-2
• 化学式: C₇H₁₇NS
• 分子量: 147.285
• InChiKey: XXTFVCXEEVMYNL-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  4.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8,9,14,15,24,25,26,26alpha-八氢-14-羟基-4,12-二甲基-3-(1-甲基乙基)-(3R,4R,5E,10E,12E,14S,26alphaR)-3H-21,18-次氮基-1H,22H-吡咯并[2,1-c][1,8,4,19]二氧杂二氮杂二十四环-1,7,16,22(4H,17H)-四酮 、 (R)-1-diethylamino-2-propanethiol 生成 (6R,7R,10R,11R,12E,17E,19E,21S)-6-[(2R)-1-(diethylamino)propan-2-yl]sulfanyl-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone
  参考文献：
  名称：

  BARRIERE, JEAN-CLAUDE;BASTART, JEAN-PIERRE;PARIS, JEAN-MARC

  摘要：

  DOI：
• 作为产物：
  描述：

  (2R)-N,N-diethyl-2-sulfanylpropanamide 生成 (R)-1-diethylamino-2-propanethiol
  参考文献：
  名称：

  BARRIERE, JEAN-CLAUDE;BASTART, JEAN-PIERRE;PARIS, JEAN-MARC

  摘要：

  DOI：

文献信息

• New process for the preparation of pristinamycin II.sub.B derivatives
  申请人：Rhone-Poulenc Sante

  公开号：US04775753A1

  公开（公告）日：1988-10-04

  Pristinamycin II.sub.B derivatives of formula I in which R represents: ##STR1## either a 4- to 7-membered nitrogen-containing heterocyclic radical, optionally containing 1 or more other hetero atoms chosen from nitrogen, oxygen and sulphur in the sulphoxide or sulphone form, and unsubstituted or substituted by alkyl, or alkyl of 2 to 4 carbon atoms, substituted by 1 or 2 radicals chosen from phenyl, cycloalkylamino or N-alkyl-N-cycloalkylamino having 3 to 6 ring carbon atoms, alkylamino, dialkylamino or dialkylcarbamoyloxy (the alkyl parts of these last 2 radicals being optionally joined to form, with the nitrogen atom to which they are attached, a 4- to 7-membered saturated or unsaturated heterocycle optionally containing another hetero atom chosen from nitrogen, oxygen and sulphur in the sulphoxide or sulphone form, and unsubstituted or substituted by alkyl) or a said alkyl substituted by one or more 4- or 7-membered nitrogen-containing heterocycles optionally containing 1 or 2 other hetero atoms chosen from nitrogen, oxygen and sulphur in the sulphoxide or sulphone form and unsubstituted or substituted by an alkyl radical, the said heterocycles being attached to the alkyl via a carbon atom, at least one of the substituents carried by the alkyl being a nitrogen-containing substituent capable of forming salts, or a [(S)-1-methyl-2-pyrrolidinyl]methyl radical, the aforesaid alkyl radicals being straight-chain or branched and containing, unless otherwise stated, 1 to 10 carbon atoms each, including isomeric forms thereof and mixtures thereof, and the salts thereof, are made by oxidizing a pristinamycin II.sub.B derivative of formula II ##STR2## with potassium peroxymonosulphate.

  在这个公式中，R代表：##STR1## 要么是一个含氮的4至7元杂环基团，可选地包含1个或多个其他异原子，选择自氮、氧和硫的硫氧化物或砜形式，并且未取代或被烷基取代，或者是含有1或2个苯基、环烷基氨基或N-烷基-N-环烷基氨基，具有3至6个环碳原子的基团的2至4个碳原子的烷基，烷基氨基，二烷基氨基或二烷基氨基羰氧基（这些最后两个基团的烷基部分可选择地与它们附着的氮原子形成，具有4至7个饱和或不饱和的杂环基团，可选地包含另一个异原子，选择自氮、氧和硫的硫氧化物或砜形式，并且未取代或被烷基取代），或者是一个被1个或多个含氮的4-或7-元杂环基团取代的上述烷基，可选地包含1个或2个其他异原子，选择自氮、氧和硫的硫氧化物或砜形式，并且未取代或被烷基取代，这些杂环基团通过一个碳原子连接到烷基上，烷基携带的取代基之一至少是能够形成盐的含氮取代基，或者是[(S)-1-甲基-2-吡咯基]甲基基团，上述烷基基团为直链或支链，并且每个基团包含1至10个碳原子，包括其同分异构体和混合物，以及其盐，通过将公式II的pristinamycin II.sub.B衍生物氧化为钾过氧单硫酸盐而制备。
• BARRIERE, JEAN-CLAUDE;BASTART, JEAN-PIERRE;PARIS, JEAN-MARC
  作者：BARRIERE, JEAN-CLAUDE、BASTART, JEAN-PIERRE、PARIS, JEAN-MARC

  DOI：——

  日期：——
• US4775753A
  申请人：——

  公开号：US4775753A

  公开（公告）日：1988-10-04