(4R)-(9CI)-4,5-二氢-2,4-双(1-甲基乙基)-噻唑 | 420134-18-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 中文名称: (4R)-(9CI)-4,5-二氢-2,4-双(1-甲基乙基)-噻唑
• 英文名称: (R)-2,4-diisopropyl-2-thiazoline
• 英文别名: (4R)-2,4-di(propan-2-yl)-4,5-dihydro-1,3-thiazole
• CAS: 420134-18-5
• 化学式: C₉H₁₇NS
• 分子量: 171.307
• InChiKey: YWOPHNXCVVZHMG-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4R)-(9CI)-4,5-二氢-2,4-双(1-甲基乙基)-噻唑 在 叔丁基锂 、 甲基磺酰氯 、 三乙胺 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 53.17h， 生成 (R,R)-2,2'-(1-methylethylidene)bis[4,5-dihydro-4-isopropylthiazoline]
  参考文献：
  名称：

  Synthesis of new chiral thiazoline-containing ligands

  摘要：

  New chiral ligands. including bi- and tridentate thiazoline derivatives, analogues of known oxazolines, have been synthesized by it general and convenient procedure. starting from dithioesters and commercial enantiopure 2-aminoalcohols. A preliminary Lest shows the ability of such ligands to act as asymmetric catalysts in Pd-catalyzed allylic substitution reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00481-5
• 作为产物：
  描述：

  D-缬氨醇 在 甲基磺酰氯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.17h， 生成 (4R)-(9CI)-4,5-二氢-2,4-双(1-甲基乙基)-噻唑
  参考文献：
  名称：

  Synthesis of new chiral thiazoline-containing ligands

  摘要：

  New chiral ligands. including bi- and tridentate thiazoline derivatives, analogues of known oxazolines, have been synthesized by it general and convenient procedure. starting from dithioesters and commercial enantiopure 2-aminoalcohols. A preliminary Lest shows the ability of such ligands to act as asymmetric catalysts in Pd-catalyzed allylic substitution reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00481-5

文献信息

• Synthesis of new chiral thiazoline-containing ligands
  作者：Isabelle Abrunhosa、Mihaela Gulea、Jocelyne Levillain、Serge Masson

  DOI：10.1016/s0957-4166(01)00481-5

  日期：2001.11

  New chiral ligands. including bi- and tridentate thiazoline derivatives, analogues of known oxazolines, have been synthesized by it general and convenient procedure. starting from dithioesters and commercial enantiopure 2-aminoalcohols. A preliminary Lest shows the ability of such ligands to act as asymmetric catalysts in Pd-catalyzed allylic substitution reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.