1,3-Dimethyl-6-(piperidylsulfonyl)-1,3-dihydroquinazoline-2,4-dione | 864544-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,3-Dimethyl-6-(piperidylsulfonyl)-1,3-dihydroquinazoline-2,4-dione
• 英文别名: 1,3-dimethyl-6-piperidin-1-ylsulfonylquinazoline-2,4-dione
• CAS: 864544-65-0
• 化学式: C₁₅H₁₉N₃O₄S
• 分子量: 337.4
• InChiKey: PKVHTZFFTVVVNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  86.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  哌啶 、 1,3-二甲基-2,4-二氧代-1,2,3,4-四氢-喹唑啉-6-磺酰氯 在 三乙胺 作用下， 以 丙酮 为溶剂， 以89%的产率得到1,3-Dimethyl-6-(piperidylsulfonyl)-1,3-dihydroquinazoline-2,4-dione
  参考文献：
  名称：

  Quinazolines 1. Synthesis and chemical reactions of 6-chlorosulfonyl-quinazoline-2,4-diones

  摘要：

  Treatment of quinazoline-2,4-dione and its symmetrical 1,3-dialkyl derivatives with chlorosulfonic acid gave the corresponding 6-chlorosulfonylquinazoline-2,4-diones. Reaction of the compounds obtained with nucleophilic agents (water, ammonia, aliphatic and cyclic amines) gave the corresponding free 2,4-dioxoquinazoline-6-sulfonic acids, 6-sulfamidoquinazoline-2,4-diones, and 2,4-dioxoquinazoline-6-sulfonic acid amides.

  DOI：

  10.1007/s10593-008-0048-y

文献信息

• Quinazolines 1. Synthesis and chemical reactions of 6-chlorosulfonyl-quinazoline-2,4-diones
  作者：R. Sh. Kuryazov、N. S. Mukhamedov、Kh. M. Shakhidoyatov

  DOI：10.1007/s10593-008-0048-y

  日期：2008.3

  Treatment of quinazoline-2,4-dione and its symmetrical 1,3-dialkyl derivatives with chlorosulfonic acid gave the corresponding 6-chlorosulfonylquinazoline-2,4-diones. Reaction of the compounds obtained with nucleophilic agents (water, ammonia, aliphatic and cyclic amines) gave the corresponding free 2,4-dioxoquinazoline-6-sulfonic acids, 6-sulfamidoquinazoline-2,4-diones, and 2,4-dioxoquinazoline-6-sulfonic acid amides.