benzofuran 3-carbohydrazide | 1339781-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: benzofuran 3-carbohydrazide
• 英文别名: 1-Benzofuran-3-carbohydrazide；1-benzofuran-3-carbohydrazide
• CAS: 1339781-33-7
• 化学式: C₉H₈N₂O₂
• 分子量: 176.175
• InChiKey: HACZCIKBRNIWBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzofuran 3-carbohydrazide 、 对甲基苯甲醛 以 乙醇 为溶剂， 反应 6.0h， 以78%的产率得到N'-(4-methylbenzylidene)benzofuran-3-carbohydrazide
  参考文献：
  名称：

  Novel N′-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents

  摘要：

  Tuberculosis constitutes today a serious threat to human health worldwide, aggravated by the increasing number of identified multi-drug resistant strains of Mycobacterium tuberculosis (Mtb), its causative agent, as well as by the lack of development of novel mycobactericidal compounds for the last few decades. A novel series of benzofuran-3-carbohydrazide and its analogs was synthesized and characterized spectroscopically. All the compounds were characterized and screened for in vitro anti-tuberculosis (anti-TB) activity against Mycobacterium tuberculosis H37Rv strains by using resazurin assay utilizing microtiter-plate method (REMA). These compounds also showed good antifungal activity against Candida albicans. Thus, the high level of activity shown by the compounds (8a, 8k) suggests that these compounds could serve as leads for development of novel synthetic compounds with enhanced anti- TB and antifungal activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.067
• 作为产物：
  描述：

  苯并呋喃-3-羧酸乙酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 benzofuran 3-carbohydrazide
  参考文献：
  名称：

  Novel N′-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents

  摘要：

  Tuberculosis constitutes today a serious threat to human health worldwide, aggravated by the increasing number of identified multi-drug resistant strains of Mycobacterium tuberculosis (Mtb), its causative agent, as well as by the lack of development of novel mycobactericidal compounds for the last few decades. A novel series of benzofuran-3-carbohydrazide and its analogs was synthesized and characterized spectroscopically. All the compounds were characterized and screened for in vitro anti-tuberculosis (anti-TB) activity against Mycobacterium tuberculosis H37Rv strains by using resazurin assay utilizing microtiter-plate method (REMA). These compounds also showed good antifungal activity against Candida albicans. Thus, the high level of activity shown by the compounds (8a, 8k) suggests that these compounds could serve as leads for development of novel synthetic compounds with enhanced anti- TB and antifungal activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.067

文献信息

• Novel N′-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents
  作者：Vikas N. Telvekar、Anirudh Belubbi、Vinod Kumar Bairwa、Kalpana Satardekar

  DOI：10.1016/j.bmcl.2012.01.067

  日期：2012.3

  Tuberculosis constitutes today a serious threat to human health worldwide, aggravated by the increasing number of identified multi-drug resistant strains of Mycobacterium tuberculosis (Mtb), its causative agent, as well as by the lack of development of novel mycobactericidal compounds for the last few decades. A novel series of benzofuran-3-carbohydrazide and its analogs was synthesized and characterized spectroscopically. All the compounds were characterized and screened for in vitro anti-tuberculosis (anti-TB) activity against Mycobacterium tuberculosis H37Rv strains by using resazurin assay utilizing microtiter-plate method (REMA). These compounds also showed good antifungal activity against Candida albicans. Thus, the high level of activity shown by the compounds (8a, 8k) suggests that these compounds could serve as leads for development of novel synthetic compounds with enhanced anti- TB and antifungal activity. (C) 2012 Elsevier Ltd. All rights reserved.