2-羟基-5-硝基-alpha-甲苯磺酸 | 18690-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2-羟基-5-硝基-alpha-甲苯磺酸
• 中文别名: 2-羟基-5-硝基-α-甲苯磺酸
• 英文名称: 5-Nitro-o-hydroxy-α-toluolsulfonsaeure
• 英文别名: (2-hydroxy-5-nitro-phenyl)-methanesulfonic acid；(2-Hydroxy-5-nitro-phenyl)-methansulfonsaeure；2-Hydroxy-5-nitro-alpha-toluenesulfonic acid；(2-hydroxy-5-nitrophenyl)methanesulfonic acid
• CAS: 18690-42-1
• 化学式: C₇H₇NO₆S
• 分子量: 233.202
• InChiKey: VZGUELDCIMLXIM-UHFFFAOYSA-N

物化性质

• 密度：
  1.733±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  2-羟基-5-硝基-alpha-甲苯磺酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (5-amino-2-hydroxy-phenyl)-methanesulfonic acid
  参考文献：
  名称：

  Marckwald; Frahne, Chemische Berichte, 1898, vol. 31, p. 1861

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯甲基-4-硝基苯酚 在 水 、 sodium sulfite 作用下， 生成 2-羟基-5-硝基-alpha-甲苯磺酸
  参考文献：
  名称：

  DE150313

  摘要：

  公开号：

文献信息

• METHOD OF DETERMINING CARBONIC ANHYDRASE I ACTIVITY
  申请人：YAMASA CORPORATION

  公开号：EP1734132A1

  公开（公告）日：2006-12-20

  To provide a method for specifically determining CA isozyme activity. The method for determining hydrolase activity of carbonic anhydrase I (CAI) in a sample, which is characterized in that the method employs, as a substrate or a combination of a substrate and an inhibitor, any of the following (A) to (E): (A) Substrate: a substrate having higher reactivity with CAI than with CAII; (B) Substrate: a substrate having higher reactivity with CAI than with CAII, Inhibitor: an inhibitor inhibiting a hydrolase other than CA, and an optional drug for enhancing inhibitory activity of the inhibitor; (C) Substrate: a substrate having higher reactivity with CAI than with CAII, and Inhibitor: a CA inhibitor inhibiting both CAI and CAII; (D) Substrate: a substrate having reactivity with both CAI and CAII, and Inhibitor: a CA inhibitor inhibiting CAI more potently than CAII; and (E) Substrate: a substrate having higher reactivity with CAI than with CAII, and Inhibitor: a CA inhibitor inhibiting CAI more potently than CAII.

  提供一种特异性测定 CA 同工酶活性的方法。 确定样品中碳酸酐酶Ⅰ（CAI）水解酶活性的方法，其特征在于该方法采用以下（A）至（E）中的任一种作为底物或底物与抑制剂的组合： (A) 底物：与 CAI 的反应活性高于与 CAII 的反应活性的底物； (B) 底物：与 CAI 的反应活性高于与 CAII 的反应活性的底物、 抑制剂：抑制 CA 之外的水解酶的抑制剂，以及 增强抑制剂抑制活性的可选药物； (C) 底物：与 CAI 的反应活性高于与 CAII 的反应活性的底物，以及 抑制剂：同时抑制 CAI 和 CAII 的 CA 抑制剂； (D) 底物：与 CAI 和 CAII 都有反应性的底物，以及 抑制剂：对 CAI 的抑制作用强于 CAII 的 CA 抑制剂；以及 (E) 底物：与 CAI 的反应活性高于与 CAII 的反应活性的底物，以及 抑制剂：对 CAI 的抑制作用强于 CAII 的 CA 抑制剂。
• Method of determining carbonic anhydrase i activity
  申请人：Hamaoki Masaru

  公开号：US20070196885A1

  公开（公告）日：2007-08-23

  To provide a method for specifically determining CA isozyme activity. The method for determining hydrolase activity of carbonic anhydrase I (CAI) in a sample, which is characterized in that the method employs, as a substrate or a combination of a substrate and an inhibitor, any of the following (A) to (E): (A) Substrate: a substrate having higher reactivity with CAI than with CAII; (B) Substrate: a substrate having higher reactivity with CAI than with CAII; Inhibitor: an inhibitor inhibiting a hydrolase other than CA, and an optional drug for enhancing inhibitory activity of the inhibitor; (C) Substrate: a substrate having higher reactivity with CAI than with CAII, and Inhibitor: a CA inhibitor inhibiting both CAI and CAII; (D) Substrate: a substrate having reactivity with both CAI and CAII, and Inhibitor: a CA inhibitor inhibiting CAI more potently than CAII; and (E) Substrate: a substrate having higher reactivity with CAI than with CAII, and Inhibitor: a CA inhibitor inhibiting CAI more potently than CAII.