N,N-diethyl-1-(4-methylphenyl)-2-naphthamide | 1415045-84-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-diethyl-1-(4-methylphenyl)-2-naphthamide
• 英文别名: N,N-Diethyl-1-(4-methylphenyl)-2-naphthamide；N,N-diethyl-1-(4-methylphenyl)naphthalene-2-carboxamide
• CAS: 1415045-84-9
• 化学式: C₂₂H₂₃NO
• 分子量: 317.431
• InChiKey: OAEZAGQRPYAYSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-Methoxynaphthalin-2-carbonsaeurechlorid 在 RuH₂(CO)(PPh₃)₃ 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 20.0h， 生成 N,N-diethyl-1-(4-methylphenyl)-2-naphthamide
  参考文献：
  名称：

  除了定向邻位金属化：钌催化酰胺-定向ç氩与硼酸酯的芳基的Naphthamides激活-OMe /交叉偶联反应

  摘要：

  描述了一种新的通用合成方法，该方法通过钌催化邻甲氧基萘酰胺与芳基硼烷戊酸酯的交叉偶联来构建联芳基，杂联芳基和聚芳基分子。异构的1-MeO-2-萘酰胺和2-MeO-1-萘酰胺以优异的收率提供了一系列芳基化萘酰胺。竞争实验表明1-MeO-2-萘酰胺比2-MeO-苯甲酰胺具有更高的反应性。建立了C–O活化/交叉偶联与Suzuki–Miyaura反应之间的正交性。该方法提供了难以通过定向原位金属化制备的萘。

  DOI：

  10.1021/acs.orglett.5b01913

文献信息

• Compounds and Methods for Catalytic Directed ortho Substitution of Aromatic Amides and Esters
  申请人：Zhao Yigang

  公开号：US20120302752A1

  公开（公告）日：2012-11-29

  Methods are described for efficient and regioselective reactions that are Ru-catalyzed and either (i) amide-directed C—H, C—N, C—O activation/C—C bond forming reactions, (ii) ester-directed C—O and C—N activation/C—C bond forming reactions, or (iii) amide-directed C—O activation/hydrodemethoxylation reactions. All of these reactions of directed C—H, C—N, C—O activation/coupling reactions establish a catalytic base-free DoM-cross coupling process at non-cryogenic temperature. High regioselectivity, yields, operational simplicity, low cost, and convenient scale-up make these reactions suitable for industrial applications. Many previously unknown amide-substituted or ester-substituted aryl and heteroaryl compounds are presented with synthetic details also provided.

  描述了一种高效和区域选择性反应的方法，这些反应是以钌为催化剂的，可以是（i）酰胺导向的C—H、C—N、C—O活化/C—C键形成反应，（ii）酯导向的C—O和C—N活化/C—C键形成反应，或者（iii）酰胺导向的C—O活化/脱甲氧基反应。所有这些导向C—H、C—N、C—O活化/偶联反应在非低温下建立了一个无催化剂碱的DoM-交叉偶联过程。高区域选择性、产率、操作简便、低成本和便于放大规模使得这些反应适用于工业应用。还提供了许多以前未知的酰胺取代或酯取代的芳基和杂环芳基化合物，同时提供了合成细节。
• NON-AQUEOUS ELECTROLYTIC SOLUTION, ELECTROCHEMICAL ELEMENT USING SAME, AND ALKYNYL COMPOUND USED THEREFOR
  申请人：Abe Koji

  公开号：US20120301797A1

  公开（公告）日：2012-11-29

  The present invention provides an excellent nonaqueous electrolytic solution capable of improving low-temperature and high-temperature cycle properties and load characteristics after high-temperature charging storage, an electrochemical element using it, and an alkynyl compound used for it. The nonaqueous electrolytic solution of the present invention comprises containing at least one alkynyl compound represented by the following general formula (I) in an amount of from 0.01 to 10% by mass in the nonaqueous electrolytic solution. R 1 (O) n —X 1 —R 2 (I) (In the formula, X 1 represents a group —C(═O)—, a group —C(═O)—C(═O)—, a group —S(═O) 2 —, a group —P(═O) (—R 3 )—, or a group —X 2 —S(═O) 2 O—. R 1 represents an alkenyl group, a formyl group, an alkyl group, an acyl group, an arylcarbonyl, an alkanesulfonyl group, an alkynyloxysulfonyl group, an arylsulfonyl group, a dialkylphosphoryl group, an alkyl(alkoxy)phosphoryl group, or a dialkoxyphosphoryl group; R 2 represents an alkynyl group or an alkynyloxy group; R 3 represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkoxy group, an alkenyloxy group, an alkynyloxy group, or an aryloxy group; n indicates 0 or 1.

  本发明提供了一种优秀的非水电解质溶液，能够改善低温和高温循环性能以及高温充电存储后的负载特性，以及使用它的电化学元件和用于它的炔基化合物。本发明的非水电解质溶液包括以下通式（I）表示的至少一种炔基化合物，其在非水电解质溶液中的质量分数为0.01至10%。R1（O）n—X1—R2（I）（在式中，X1表示基团—C(═O)—，基团—C(═O)—C(═O)—，基团—S(═O)2—，基团—P(═O)(—R3)—，或基团—X2—S(═O)2O—。R1表示烯基基团，甲酰基团，烷基基团，酰基团，芳基羰基，烷烷基磺酰基，炔氧基磺酰基，芳基磺酰基，二烷基磷酰基，烷基(烷氧基)磷酰基，或二烷氧基磷酰基；R2表示炔基团或炔氧基团；R3表示烷基，烯基，炔基，芳基，烷氧基，烯氧基，炔氧基，或芳氧基；n表示0或1。
• Non-aqueous electrolytic solution, electrochemical element using the same and alkynyl compound used therefor
  申请人：Ube Industries, Ltd.

  公开号：EP2883867A2

  公开（公告）日：2015-06-17

  The present invention provides an excellent nonaqueous electrolytic solution capable of improving low-temperature and high-temperature cycle properties and load characteristics after high-temperature charging storage, an electrochemical element using it, and an alkynyl compound used for it. The nonaqueous electrolytic solution of the present invention comprises at least one alkynyl compound represented by the following general formula (I) in an amount of from 0.01 to 10% by mass in the nonaqueous electrolytic solution.          R1(O)n-X1-R2     (I) In the formula, X1 represents a group -C(=O)-, a group -S(=O)2-, or a group -P(=O)(-R3)-. R1 represents an alkenyl group having from 2 to 8 carbon atoms; R2 represents an alkynyl group having from 3 to 8 carbon atoms or an alkynyloxy group having from 3 to 8 carbon atoms; R3 represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkoxy group, an alkenyloxy group, an alkynyloxy group, or an aryloxy group; n indicates 0 or 1.

  本发明提供了一种能够改善低温和高温循环特性以及高温充电储存后负载特性的优良非水基电解溶液、使用该溶液的电化学元件以及用于该溶液的炔基化合物。 本发明的非水基电解溶液包含至少一种由下式通式（I）表示的炔基化合物，其在非水基电解溶液中的含量为 0.01 至 10%（按质量计）。 R1(O)n-X1-R2 (I) 式中，X1 代表基团-C(=O)-、基团-S(=O)2-或基团-P(=O)(-R3)-。R1 代表具有 2 至 8 个碳原子的烯基；R2 代表具有 3 至 8 个碳原子的炔基或具有 3 至 8 个碳原子的炔氧基；R3 代表烷基、烯基、炔基、芳基、烷氧基、烯氧基、炔氧基或芳氧基；n 表示 0 或 1。
• NON-AQUEOUS ELECTROLYTIC SOLUTION, ELECTROCHEMICAL ELEMENT USING THE SAME, AND ALKYNYL COMPOUND USED THEREFOR
  申请人：Ube Industries, Ltd.

  公开号：EP2533344B1

  公开（公告）日：2016-07-20
• US9647294B2
  申请人：——

  公开号：US9647294B2

  公开（公告）日：2017-05-09