2-Phenyl-3-acetoxy-1H-indene | 131080-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 2-Phenyl-3-acetoxy-1H-indene
• 英文别名: 2-phenyl-1H-inden-3-yl acetate；acetic acid-(2-phenyl-inden-3-yl ester)；3-Acetoxy-2-phenyl-inden；Essigsaeure-(2-phenyl-inden-3-ylester)；(2-Phenyl-indenyl-(3))-acetat；(2-phenyl-3H-inden-1-yl) acetate
• CAS: 131080-09-6
• 化学式: C₁₇H₁₄O₂
• 分子量: 250.297
• InChiKey: KETVTLPCMDPDAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Phenyl-3-acetoxy-1H-indene 在 臭氧 作用下， 以 二氯甲烷 为溶剂， 以65%的产率得到2-Phenyl-3-acetoxy-1H-indene ozonide
  参考文献：
  名称：

  Ozonolysis of 2-phenyl-3-(acyloxy)-1H-indenes and 1-phenyl-2-(benzoyloxy)acenaphthylene. Intramolecular carbonyl oxide-(acyloxy)carbonyl cycloaddition

  摘要：

  DOI：

  10.1021/jo00004a061
• 作为产物：
  描述：

  2-苯基-1-茚酮 、 乙酰氯 在 sodium hydride 作用下， 生成 2-Phenyl-3-acetoxy-1H-indene
  参考文献：
  名称：

  Ozonolysis of 2-phenyl-3-(acyloxy)-1H-indenes and 1-phenyl-2-(benzoyloxy)acenaphthylene. Intramolecular carbonyl oxide-(acyloxy)carbonyl cycloaddition

  摘要：

  DOI：

  10.1021/jo00004a061

文献信息

• The Electrophilic Fluorination of Enol Esters Using SelectFluor: A Polar Two‐Electron Process
  作者：Susanna H. Wood、Stephen Etridge、Alan R. Kennedy、Jonathan M. Percy、David J. Nelson

  DOI：10.1002/chem.201900029

  日期：2019.4.11

  facile and leads to the corresponding α‐fluoroketones under mild conditions and, as a result, this route is commonly employed for the synthesis of medicinally important compounds such as fluorinated steroids. However, despite the use of this methodology in synthesis, the mechanism of this reaction and the influence of structure on reactivity are unclear. A rigorous mechanistic study of the fluorination

  烯醇酯与SelectFluor的反应很容易，并且在温和条件下会生成相应的α-氟代酮，因此，该路线通常用于合成重要的药用化合物，例如氟化类固醇。然而，尽管在合成中使用了该方法，但是该反应的机理和结构对反应性的影响尚不清楚。提出了对这些底物氟化的严格机理的研究，主要是通过详细而可靠的动力学实验得出的信息。这项研究的结果暗示了通过氧稳定的碳鎓物质进行的极性双电子过程，而不是涉及自由基中间体的单电子过程。
• Malingered psychosis
  作者：Nicholas Broughton、Paul Chesterman

  DOI：10.1080/09585180110056795

  日期：2001.1

  The diagnosis of mental illness is heavily reliant on both the honesty and the accuracy of patient statements. Traditionally the veracity of such statements has been assumed; however, particularly in the forensic field, such an assumption may often prove to be naive. The case-example that follows concerns a man convicted of indecently assaulting a teenage boy. He presented to forensic services with a variety of psychotic symptoms, which were subsequently proven to be feigned. The case exemplifies certain typical features of malingered psychosis as described in the American literature; however, it is also unusual in a number of ways. It serves to demonstrate that the careful assessment of possible malingering is a fundamental issue for all psychiatrists, especially where the therapeutic alliance may be complicated by external sociolegal issues which could possibly, serve as motivation for the fabrication of psychopathology.
• Ozonolysis of 2-phenyl-3-(acyloxy)-1H-indenes and 1-phenyl-2-(benzoyloxy)acenaphthylene. Intramolecular carbonyl oxide-(acyloxy)carbonyl cycloaddition
  作者：Toshiya Sugimoto、Norinaga Nakamura、Masatomo Nojima、Shigekazu Kusabayashi

  DOI：10.1021/jo00004a061

  日期：1991.2