(Z)-N-(2-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-ylidene)aniline | 1262424-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (Z)-N-(2-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-ylidene)aniline
• CAS: 1262424-51-0
• 化学式: C₂₄H₁₉N₃
• 分子量: 349.435
• InChiKey: HVTKPGBMAJSCOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.63
• 重原子数：
  27.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  36.42
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (Z)-N-(2-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-ylidene)aniline 在 potassium permanganate 作用下， 以 丙酮 为溶剂， 以54%的产率得到2-(naphthalen-1-yl)-N-phenylquinazolin-4-amine
  参考文献：
  名称：

  Iodine-promoted facile synthesis of new (+)-2,3-dihydro-N,2-diarylquinazolines

  摘要：

  The reactivity of 2-amino-N'-arylbenzamidines 1a-e towards p-tolualdehyde 2a and 1-naphthaldehyde 2b under the catalytic influence of commercial iodine at ambient temperature has been examined. New chiral quinazolines 3a-e and 4a-d have been identified as reaction products. These products have subsequently been oxidised to N,2-diarylquinazolin-4-amines 12, 13a-d. The structures of the products were elucidated by their NMR, mass and IR spectra in addition to elemental analyses. The structure of 3e was further confirmed by X-ray structural analysis. The mechanism of formation of 3a-e and 4a-d is discussed.

  DOI：

  10.3998/ark.5550190.0011.a09
• 作为产物：
  描述：

  1-萘甲醛 、 2-amino-N'-phenylbenzamidine 在 碘 作用下， 以 乙醇 为溶剂， 以67%的产率得到(Z)-N-(2-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-ylidene)aniline
  参考文献：
  名称：

  Iodine-promoted facile synthesis of new (+)-2,3-dihydro-N,2-diarylquinazolines

  摘要：

  The reactivity of 2-amino-N'-arylbenzamidines 1a-e towards p-tolualdehyde 2a and 1-naphthaldehyde 2b under the catalytic influence of commercial iodine at ambient temperature has been examined. New chiral quinazolines 3a-e and 4a-d have been identified as reaction products. These products have subsequently been oxidised to N,2-diarylquinazolin-4-amines 12, 13a-d. The structures of the products were elucidated by their NMR, mass and IR spectra in addition to elemental analyses. The structure of 3e was further confirmed by X-ray structural analysis. The mechanism of formation of 3a-e and 4a-d is discussed.

  DOI：

  10.3998/ark.5550190.0011.a09