α-Phenyl-isohexylamin | 17061-54-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: α-Phenyl-isohexylamin
• 英文别名: α-Isopentyl-benzylamin；4-methyl-1-phenyl-pentylamine；4-Methyl-1-phenylpentan-1-amine
• CAS: 17061-54-0
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: IEGVLAUQRYYJJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-甲基-1-苯基戊烷-1-酮 生成 α-Phenyl-isohexylamin
  参考文献：
  名称：

  de Roocker,A.; de Radzitzky,P., Bulletin des Societes Chimiques Belges, 1963, vol. 72, p. 202 - 207

  摘要：

  DOI：

文献信息

• Niinobe, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1943, vol. 63, p. 209
  作者：Niinobe

  DOI：——

  日期：——
• SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER
  申请人：President and Fellows of Harvard College

  公开号：US20170072390A1

  公开（公告）日：2017-03-16

  The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
• US9724682B2
  申请人：——

  公开号：US9724682B2

  公开（公告）日：2017-08-08
• [EN] NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION<br/>[FR] NOUVEAUX INHIBITEURS DE RÉPLICATION DU VIRUS DE L'HÉPATITE C
  申请人：INTERMUNE INC

  公开号：WO2009134616A2

  公开（公告）日：2009-11-05

  The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
• de Roocker,A.; de Radzitzky,P., Bulletin des Societes Chimiques Belges, 1963, vol. 72, p. 202 - 207
  作者：de Roocker,A.、de Radzitzky,P.

  DOI：——

  日期：——