trans-4-Isopropyl-cyclohexyl-dimethylamin | 19479-46-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: trans-4-Isopropyl-cyclohexyl-dimethylamin
• CAS: 19479-46-0
• 化学式: C₁₁H₂₃N
• 分子量: 169.31
• InChiKey: PFNTYHJEBMOBFD-XYPYZODXSA-N

物化性质

• 沸点：
  220.3±8.0 °C(Predicted)
• 密度：
  0.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.76
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.24
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 trans-4-isopropylcyclohexylamine 在 甲酸 作用下， 生成 trans-4-Isopropyl-cyclohexyl-dimethylamin
  参考文献：
  名称：

  Sicher,J. et al., Collection of Czechoslovak Chemical Communications, 1968, vol. 33, p. 1438 - 1450

  摘要：

  DOI：

文献信息

• Substituted Benzene Compounds
  申请人：Epizyme, Inc.

  公开号：US20140315945A1

  公开（公告）日：2014-10-23

  The present invention relates to azole compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及唑类化合物。本发明还涉及含有这些化合物的药物组合物以及通过向需要的受试者投予这些化合物和药物组合物来治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的用途。
• Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use
  申请人：Greig Iain Robert

  公开号：US20110172189A1

  公开（公告）日：2011-07-14

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc. Formula (I).

  本发明涉及治疗化合物领域，更具体地涉及以下公式的某些芳基-苯基-磺酰胺基环烷化合物（统称为“APSAC化合物”）。本发明还涉及包含这种化合物的制药组合物以及在体内外使用这种化合物和组合物治疗炎症、关节破坏和/或骨质流失等问题，治疗由免疫系统过度和/或不适当和/或持久活化引起的疾病，如类风湿性关节炎、牛皮癣、银屑病性关节炎、慢性阻塞性肺疾病（COPD）、动脉粥样硬化、炎症性肠病、强直性脊柱炎等炎症和自身免疫性疾病，以及与骨质流失相关的疾病，如类风湿性关节炎、骨质疏松症、癌症相关骨病、帕吉特病等，以及癌症，如血液系统恶性肿瘤、实体瘤等。公式（I）。
• ETHER DERIVATIVES OF BICYCLIC HETEROARYLS
  申请人：Chen Bei

  公开号：US20120165310A1

  公开（公告）日：2012-06-28

  The invention relates to compounds of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease.

  本发明涉及式I的化合物，其中取代基如规范中所定义；制备此类化合物的方法；包含此类化合物的制药组合物；此类化合物作为药物；此类化合物用于治疗增生性疾病。
• Substituted 6,5-Fused Bicyclic Heteroaryl Compounds
  申请人：Epizyme, Inc.

  公开号：US20140296283A1

  公开（公告）日：2014-10-02

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及杂环双环杂芳基化合物。本发明还涉及含有这些化合物的药物组合物以及通过将这些化合物和药物组合物用于需要的受试者治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的使用。
• Substituted 6, 5-Fused Bicyclic Heteroaryl Compounds
  申请人：EPIZYME, INC.

  公开号：US20150246916A1

  公开（公告）日：2015-09-03

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及杂环双环杂芳烃化合物。本发明还涉及含有这些化合物的药物组合物以及通过将这些化合物和药物组合物用于需要的受试者治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的用途。