N-bromoacetyl-L-valine-tert-butylamide | 383413-10-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: N-bromoacetyl-L-valine-tert-butylamide
• 英文别名: N-bromoacetyl-l-valine-t-butyl-amide；(2S)-2-[(2-bromoacetyl)amino]-N-tert-butyl-3-methylbutanamide
• CAS: 383413-10-3
• 化学式: C₁₁H₂₁BrN₂O₂
• 分子量: 293.204
• InChiKey: MMJVOYKNIIHLPT-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  C-dec-1-enylresorcinarene 、 N-bromoacetyl-L-valine-tert-butylamide 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 36.0h， 以68%的产率得到octakis-O-(acetyl-L-valine-tert-butylamide)-C-decenyl-resorcinarene
  参考文献：
  名称：

  Synthesis of an enantiomerically pure resorcinarene with pendant l-valine residues and its attachment to a polysiloxane (Chirasil-Calix)

  摘要：

  The synthesis of a new enantiomerically pure resorcinarene by reaction of all resorcinic groups with N-brornoacetyl-L-valine-tert-butyl-amide is described. The chiral macrocyclic product was chemically bonded to a poly(hydro)dimethylsiloxane by hydrosilylation using a platinum catalyst. The resulting chiral polysiloxane Chirasil-Calix can be used as chiral stationary phase (CSP) in capillary gas chromatography. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00352-4
• 作为产物：
  描述：

  Boc-L-valine-tert-butylamide 在 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 生成 N-bromoacetyl-L-valine-tert-butylamide
  参考文献：
  名称：

  Synthesis of an enantiomerically pure resorcinarene with pendant l-valine residues and its attachment to a polysiloxane (Chirasil-Calix)

  摘要：

  The synthesis of a new enantiomerically pure resorcinarene by reaction of all resorcinic groups with N-brornoacetyl-L-valine-tert-butyl-amide is described. The chiral macrocyclic product was chemically bonded to a poly(hydro)dimethylsiloxane by hydrosilylation using a platinum catalyst. The resulting chiral polysiloxane Chirasil-Calix can be used as chiral stationary phase (CSP) in capillary gas chromatography. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00352-4

文献信息

• Synthesis of an enantiomerically pure resorcinarene with pendant l-valine residues and its attachment to a polysiloxane (Chirasil-Calix)
  作者：Alexander Ruderisch、Jens Pfeiffer、Volker Schurig

  DOI：10.1016/s0957-4166(01)00352-4

  日期：2001.8

  The synthesis of a new enantiomerically pure resorcinarene by reaction of all resorcinic groups with N-brornoacetyl-L-valine-tert-butyl-amide is described. The chiral macrocyclic product was chemically bonded to a poly(hydro)dimethylsiloxane by hydrosilylation using a platinum catalyst. The resulting chiral polysiloxane Chirasil-Calix can be used as chiral stationary phase (CSP) in capillary gas chromatography. (C) 2001 Elsevier Science Ltd. All rights reserved.