7-methoxy-2-piperazin-1-yl-quinoxaline | 760887-76-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 7-methoxy-2-piperazin-1-yl-quinoxaline
• 英文别名: 7-Methoxy-2-piperazin-1-ylquinoxaline
• CAS: 760887-76-1
• 化学式: C₁₃H₁₆N₄O
• 分子量: 244.296
• InChiKey: GEEJOLWDJAVXGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  50.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(甲氧基羰基)苯基异氰酸酯 、 7-methoxy-2-piperazin-1-yl-quinoxaline 生成
  参考文献：
  名称：

  Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A

  摘要：

  A urea class of high affinity niacin receptor agonists was discovered. Compound 1a displayed good PK, better in vivo efficacy in reducing FFA in mouse than niacin, and no vasodilation in a mouse model. Compound 1q demonstrated equal affinity to GPR109A as niacin. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.055
• 作为产物：
  描述：

  哌嗪 、 2-氯-6-甲氧基喹噁啉 以 正丁醇 为溶剂， 反应 0.5h， 生成 7-methoxy-2-piperazin-1-yl-quinoxaline
  参考文献：
  名称：

  WO2007/27532

  摘要：

  公开号：

文献信息

• Piperazinylquinoxalines with central serotoninmimetic activity
  作者：William C. Lumma、Richard D. Hartman、Walfred S. Saari、Edward L. Engelhardt、Victor J. Lotti、Clement A. Stone

  DOI：10.1021/jm00133a019

  日期：1981.1

  Regioselective syntheses of substituted 2-chloroquinoxalines and derived 2-(1-piperazinyl)quinoxalines are described. Selectivity in regards to serotonin reuptake blocking and serotoninmimetic activities of the piperazinylquinoxalines is reported. In general, introduction of a 6-substituent into the piperazinylquinoxaline enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted and 3-hydroxypiperazinylquinoxalines had primarily serotoninmimetic activity.
• WO2007/27532
  申请人：——

  公开号：——

  公开（公告）日：——
• Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A
  作者：Hong C. Shen、Michael J. Szymonifka、Divya Kharbanda、Qiaolin Deng、Ester Carballo-Jane、Kenneth K. Wu、Tsuei-Ju Wu、Kang Cheng、Ning Ren、Tian-Quan Cai、Andrew K. Taggart、Junying Wang、Xinchun Tong、M. Gerard Waters、Milton L. Hammond、James R. Tata、Steven L. Colletti

  DOI：10.1016/j.bmcl.2007.10.055

  日期：2007.12

  A urea class of high affinity niacin receptor agonists was discovered. Compound 1a displayed good PK, better in vivo efficacy in reducing FFA in mouse than niacin, and no vasodilation in a mouse model. Compound 1q demonstrated equal affinity to GPR109A as niacin. (c) 2007 Elsevier Ltd. All rights reserved.