N-decyl perfluorooctanesulfonamide | 195047-44-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: N-decyl perfluorooctanesulfonamide
• 英文别名: N-Decylperfluorooctanesulfonamide；N-decyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide
• CAS: 195047-44-0
• 化学式: C₁₈H₂₂F₁₇NO₂S
• 分子量: 639.417
• InChiKey: KJODALGXCUSVFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  39
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  全氟辛基磺酰氟 、 1-氨基癸烷 在 三乙胺 作用下， 以 异丙醚 为溶剂， 反应 4.0h， 生成 N-decyl perfluorooctanesulfonamide
  参考文献：
  名称：

  Synthesis and surface activities of organic solvent-soluble fluorinated surfactants

  摘要：

  A variety of fluorinated surfactants soluble in organic solvent were prepared, including C8F17SO2NHCnH2n+1 (n = 2, 4, 6, 8, 10), C8F17SO2NHR (R = C6H11, C6H5), C8F17SO2N(C(n)H(2)n(+1))(2) (n = 1, 2, 3, 4) and C8F17SO2NH(CH2)(n)NHO2SC8F17 (n = 6, 10). Their surface activities in various organic solvents were determined by surface tension measurement. The results showed that these fluorinated surfactants can reduce the surface tension of both polar and non-polar organic solvents. In general, organic solvents with strong polarity or long alkyl chain are beneficial to increase the surface activity of these polar fluorinated surfactants. By comparing fluorinated surfactants with the same fluorocarbon segment and connecting group, C8F17SO2N(CnH2n+1)(2) (n = 1, 2, 3, 4) showed lower surface activity in organic solvents than C8F17SO2NHCnH2n+1 (n = 2, 4, 6, 8) with an equal carbon number of the solvophilic group. Through surface tension vs. concentration curves given for N-octyl perfluorooctanesulfonamide in various organic solvents, a break point like the critical micelle concentration of ordinary surfactants in aqueous solutions was observed, and the effect of the different types of organic solvents on adsorption and aggregation behavior was also studied. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2009.05.006

文献信息

• Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
  申请人：Platzek Johannes

  公开号：US20050147563A1

  公开（公告）日：2005-07-07

  The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.

  本发明涉及新的、单体的、全氟烷基取代的金属配合物、其制备过程以及它们在诊断和治疗中的应用。本发明的化合物特别适用于核磁共振断层扫描（MRT）中的体内对比剂。它们可以优选地用作血池剂和淋巴造影剂。
• Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis
  申请人：Schering Aktiengesellschaft

  公开号：US06468502B1

  公开（公告）日：2002-10-22

  The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.

  本发明涉及新型单体的全氟烷基取代金属配合物、其制备方法以及在诊断和治疗中的应用。本发明所述的化合物特别适用于核磁共振成像（MRT）中的体内对比剂。它们可以作为血池剂和淋巴造影剂使用。
• [DE] PHARMAZEUTISCHE MITTEL ENTHALTEND PERFLUORALKYLHALTIGE METALLKOMPLEXE UND IHRE VERWENDUNG IN DER TUMORTHERAPIE UND INTERVENTIONELLEN RADIOLOGIE<br/>[EN] PHARMACEUTICAL AGENTS CONTAINING PERFLUOROALKYL-CONTAINING METAL COMPLEXES AND THE USE THEREOF IN TUMOUR THERAPY AND INTERVENTIONAL RADIOLOGY<br/>[FR] AGENTS PHARMACEUTIQUES CONTENANT DES COMPLEXES METALLIQUES PERFLUORALKYLES ET LEUR UTILISATION DANS LE TRAITEMENT DES TUMEURS ET EN RADIOLOGIE INTERVENTIONNELLE
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：WO1997030969A1

  公开（公告）日：1997-08-28

  (DE) Die Erfindung betrifft pharmazeutische Mittel enthaltend perfluoralkylierte Metallkomplexe der allgemeinen Formel (I), RF-L-A, und ihre Verwendung in der Tumortherapie und interventionellen Radiologie, worin RF eine perfluorierte, geradkettige oder verzweigte Kohlenstoffkette mit der Formel -CnF2nX ist, in der X ein endständiges Fluor-, Chlor-, Brom-, Jod- oder Wasserstoffatom darstellt und n für die Zahlen 4-30 steht, L eine bindende Gruppe, und A für ein Metallkomplex oder dessen Salze organischer und/oder anorganischer Basen oder Aminosäuren oder Aminosäureamide steht, L und A sind in der Beschreibung näher definiert.(EN) The invention relates to pharmaceutical agents containing perfluoroalkylated metal complexes of the general formula (I) RF-L-A and the use thereof in tumour therapy and interventional radiology, in which formula RF is a perfluorinated, straight-chain or branched carbon chain with the formula -CnF2nX, in which X is a terminal fluorine, chlorine, bromine, iodine or hydrogen atom and n represents the numbers 4-30, L is a binding group, and A is a metal complex or the salts thereof of organic and/or inorganic bases or amino acids or amino acid amides. L and A are defined in detail in the description.(FR) L'invention concerne des agents pharmaceutiques renfermant des complexes métalliques perfluoralkylés de la formule générale (I) RF-L-A et leur utilisation dans le traitement des tumeurs et en radiologie interventionnelle. Dans la formule précitée, RF est une chaîne carbonée perfluorée droite ou ramifiée ayant la formule -CnF2nX dans laquelle X est un atome de fluor, chlore, brome, iode ou hydrogène en fin de chaîne et n représente les nombres 4-30, L est un groupe de liaison, et A représente un complexe métallique ou ses sels de bases organiques et/ou inorganiques ou bien d'aminoacides ou encore d'amides d'aminoacides. L et A sont définis en détail dans la description.

  该发明涉及含有全氟丙基化金属化合物的一般式（I）RF-L-A及其在肿瘤治疗和介入性放射治疗中的应用。在式（I）中，RF是全氟的直线型或分枝型碳链，其化学式为-CnF2nX，其中X表示终端氟、氯、溴、碘或氢原子，n表示4至30之间的数。L是结合基团，A是金属化合物或其含有机或无机碱、氨基酸或氨基酸类胺的盐。L和A在描述中作了详细说明。
• US06180113B2
  申请人：——

  公开号：——

  公开（公告）日：——
• PERFLUORALKYLHALTIGE METALLKOMPLEXE UND IHRE VERWENDUNG IN DER NMR-DIAGNOSTIK
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP0874645B1

  公开（公告）日：2002-04-03