1-(N-amidomethyl-6-fluoresceinyl)-5-aminopentane | 205306-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-(N-amidomethyl-6-fluoresceinyl)-5-aminopentane
• CAS: 205306-55-4
• 化学式: C₂₇H₂₆N₂O₆
• 分子量: 474.513
• InChiKey: RLTJBCAJPYGWMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  35.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  131.11
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  1-(N-amidomethyl-6-fluoresceinyl)-5-aminopentane 在 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.5h， 生成 2-{[(N'-Amidomethyl-6-fluoresceinyl)-N-amidopentylcarbonyl]carbonyl}-3-carboxy methyl-1H-pyrrole-4-propanoic acid
  参考文献：
  名称：

  Synthesis of immunocomponents for the measurement of lead (Pb) by fluorescence polarization immunoassay

  摘要：

  Three novel haptens (5b, 9b, 11b) were synthesized from porphobilinogen (2) and conjugated to bovine serum albumin to afford immunogens (6, 10, 12). Five fluorescent tracers (14, 17, 19, 29, 32) were prepared from porphobilinogen (2), or haptens (9b, 11b, 20b) in >98% purity. The immunogens (6, 10, 12) were utilized for generation of polyclonal antibodies and the best tracer-antibody combination was selected to construct the calibration curve for the measurement of lead. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00060-x
• 作为产物：
  描述：

  6-t-butoxycarbonylamidopentane-1-(6-carboxamidomethyl)fluorescein 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以95%的产率得到1-(N-amidomethyl-6-fluoresceinyl)-5-aminopentane
  参考文献：
  名称：

  Synthesis of immunocomponents for the measurement of lead (Pb) by fluorescence polarization immunoassay

  摘要：

  Three novel haptens (5b, 9b, 11b) were synthesized from porphobilinogen (2) and conjugated to bovine serum albumin to afford immunogens (6, 10, 12). Five fluorescent tracers (14, 17, 19, 29, 32) were prepared from porphobilinogen (2), or haptens (9b, 11b, 20b) in >98% purity. The immunogens (6, 10, 12) were utilized for generation of polyclonal antibodies and the best tracer-antibody combination was selected to construct the calibration curve for the measurement of lead. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00060-x