(E)-non-7-en-4-amine | 55713-48-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-non-7-en-4-amine
• CAS: 55713-48-9
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: UJWMBPSAANMFDL-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-non-7-en-4-amine 在 sodium hexamethyldisilazane 作用下， 生成 ((E)-Buta-1,3-dienyl)-((E)-1-propyl-hex-4-enyl)-carbamic acid methyl ester
  参考文献：
  名称：

  （+/-）-pumiliotoxin-C的总合成。

  摘要：

  AbstractDie erste Totalsynthese des racemischen Alkaloids Pumiliotoxin‐C (9) ausgehend von trans‐1‐Brom‐3‐penten (1) wird beschrieben. Die Schlüsselstufe 6 → 7 verläuft über eine intramolekulare Diels‐Alder‐Reaktion unter weitgehender sterischer Kontrolle von vier Chiralitätszentren. Die Struktur des synthetischen Produkte 9 wurde durch eine Röntgenstrukturanalyse des kristallinen Hydrogenmaleinates bestätigt.

  DOI：

  10.1002/hlca.19750580232
• 作为产物：
  描述：

  non-7t-en-4-one oxime 在 lithium aluminium tetrahydride 作用下， 生成 (E)-non-7-en-4-amine
  参考文献：
  名称：

  （+/-）-pumiliotoxin-C的总合成。

  摘要：

  AbstractDie erste Totalsynthese des racemischen Alkaloids Pumiliotoxin‐C (9) ausgehend von trans‐1‐Brom‐3‐penten (1) wird beschrieben. Die Schlüsselstufe 6 → 7 verläuft über eine intramolekulare Diels‐Alder‐Reaktion unter weitgehender sterischer Kontrolle von vier Chiralitätszentren. Die Struktur des synthetischen Produkte 9 wurde durch eine Röntgenstrukturanalyse des kristallinen Hydrogenmaleinates bestätigt.

  DOI：

  10.1002/hlca.19750580232

文献信息

• [EN] METHODS AND TREATMENT OF VIRAL INFECTION WITH SUBSTITUTED FURO-PYRIMIDINES<br/>[FR] PROCÉDÉS ET TRAITEMENT D'INFECTION VIRALE AVEC DES FURO-PYRIMIDINES SUBSTITUÉES
  申请人：VERGE ANALYTICS INC

  公开号：WO2022261068A1

  公开（公告）日：2022-12-15

  The present disclosure provides compounds that are useful for the treatment of coronavirus infections.

  本公开提供了可用于治疗冠状病毒感染的化合物。
• AMPHIPHILIC POLYMER AND PROCESSES OF FORMING THE SAME
  申请人：Janczewski Dominik

  公开号：US20100298504A1

  公开（公告）日：2010-11-25

  Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with —COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.
• [EN] PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PDE4 INHIBITORS<br/>[FR] COMPOSÉS
  申请人：GLAXO GROUP LTD

  公开号：WO2008009735A1

  公开（公告）日：2008-01-24

  [EN] The present invention provides a compound of formula (I) or a salt thereof (in particular, a pharmaceutically acceptable salt thereof): The invention also provides the use of the compounds or salts as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis, e.g. in a mammal such as a human.
  [FR] La présente invention concerne un composé représenté par la formule (I) ou un sel de ce dernier( notamment un sel pharmaceutiquement acceptable de ce dernier). Cette invention porte également sur l'utilisation des composés ou des sels selon l'invention en tant qu'inhibiteurs de la phosphodiestérase de type IV (PDE4) et/ou pour le traitement et/ou la prévention des maladies inflammatoires et/ou allergiques telles que la maladie pulmonaire obstructive chronique (MPOC), l'asthme, la rhinite (par exemple la rhinite allergique), la dermatite atopique ou le psoriasis, par exemple chez un mammifère tel que l'homme.
• [EN] AMPHIPHILIC POLYMER AND PROCESSES OF FORMING THE SAME<br/>[FR] POLYMÈRE AMPHIPHILE ET SES PROCÉDÉS DE FABRICATION
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2009038544A1

  公开（公告）日：2009-03-26

  Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with -COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.