ethyl 2-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoacetate | 850751-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: ethyl 2-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoacetate
• 英文别名: ethyl 2-(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoacetate
• CAS: 850751-97-2
• 化学式: C₂₁H₂₃NO₅
• 分子量: 369.417
• InChiKey: DCVCFOUUKXTJPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 2-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoacetate 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成 2-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoacetic acid
  参考文献：
  名称：

  Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

  摘要：

  In our previous studies a ligand-based approach led to the identification of noncompetitive AMPA receptor antagonists containing isoquinoline scaffold. In an attempt to perform a systematic SAR study, we synthesized new N-substituted-isoquinolines bearing the most salient features described by our 3D pharmacophore model. All compounds were screened against audiogenic seizures and some derivatives showed anticonvulsant properties. Compound 24, the most active of the series, was also tested in vitro using the patch-clamp technique and proved to antagonize AMPA-mediated effects. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.11.071
• 作为产物：
  描述：

  6,7-二甲氧基-1-苯基-1,2,3,4-四氢异喹啉 、 草酰氯单乙酯 以 二氯甲烷 为溶剂， 反应 0.08h， 生成 ethyl 2-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoacetate
  参考文献：
  名称：

  Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

  摘要：

  In our previous studies a ligand-based approach led to the identification of noncompetitive AMPA receptor antagonists containing isoquinoline scaffold. In an attempt to perform a systematic SAR study, we synthesized new N-substituted-isoquinolines bearing the most salient features described by our 3D pharmacophore model. All compounds were screened against audiogenic seizures and some derivatives showed anticonvulsant properties. Compound 24, the most active of the series, was also tested in vitro using the patch-clamp technique and proved to antagonize AMPA-mediated effects. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.11.071

文献信息

• Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists
  作者：Rosaria Gitto、Laura De Luca、Benedetta Pagano、Rita Citraro、Giovanbattista De Sarro、Lara Costa、Lucia Ciranna、Alba Chimirri

  DOI：10.1016/j.bmc.2007.11.071

  日期：2008.3

  In our previous studies a ligand-based approach led to the identification of noncompetitive AMPA receptor antagonists containing isoquinoline scaffold. In an attempt to perform a systematic SAR study, we synthesized new N-substituted-isoquinolines bearing the most salient features described by our 3D pharmacophore model. All compounds were screened against audiogenic seizures and some derivatives showed anticonvulsant properties. Compound 24, the most active of the series, was also tested in vitro using the patch-clamp technique and proved to antagonize AMPA-mediated effects. (C) 2007 Elsevier Ltd. All rights reserved.