7-carbamoylbenzo-1,2,3-thiadiazole | 124370-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻二唑类
• 英文名称: 7-carbamoylbenzo-1,2,3-thiadiazole
• 英文别名: benzo-1,2,3-thiadiazole-7-carboxylic acid amide；benzo-1,2,3-thiadiazole-7-carboxamide；7-carboxamide-benzothiadiazole；1,2,3-benzothiadiazole-7-carboxamide
• CAS: 124370-91-8
• 化学式: C₇H₅N₃OS
• 分子量: 179.202
• InChiKey: LXDHQFIXZWZUGL-UHFFFAOYSA-N

物化性质

• 沸点：
  422.6±37.0 °C(Predicted)
• 密度：
  1.516±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-carbamoylbenzo-1,2,3-thiadiazole 、 三氟乙酸酐 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 以99%的产率得到Benzo[1,2,3]thiadiazole-7-nitrile
  参考文献：
  名称：

  Process and a composition for immunizing plants against diseases

  摘要：

  一种用于对健康有益的植物进行免疫接种以防止植物病害的方法和组合物，其中活性成分是公式##STR1##的化合物，其中：X是氢、卤素、羟基、甲基、甲氧基、羧基或甲氧羧基；Y是氢、卤素、磺酸基、甲磺酸基、硝基、羟基或氨基，M是一个碱金属或碱土金属离子的摩尔当量，该金属离子由相应的碱或碱性化合物形成；Z是氰基或--CO--A；A代表--OH或--SH，其中的氢原子也可以被无机或有机阳离子残基的摩尔当量所取代，或者其中A代表任意的其它有机残基，其分子量小于900，并且也可以包含一个或多个杂原子，包括与初级、次级或三级胺或无机碱形成的植物生理上可容忍的7-羧酸或7-硫羧酸的盐。

  公开号：

  US04931581A1
• 作为产物：
  描述：

  Benzo[1,2,3]thiadiazole-7-nitrile 在 氢氧化钾 作用下， 以 正丁醇 为溶剂， 生成 7-carbamoylbenzo-1,2,3-thiadiazole
  参考文献：
  名称：

  Process for the preparation of substituted 3-aminobenzonitriles

  摘要：

  该发明涉及一种制备取代3-氨基苯腈的过程，包括将适当的取代3-氨基氯苯与氰基供体试剂反应，以及由此产生的化合物。这些化合物是中间体，经进一步反应后可产生具有植物免疫性能的1,2,3-苯并噻二唑衍生物。

  公开号：

  US05883283A1

文献信息

• Compositions for protecting plants against disease
  申请人：Ciba-Geigy Corporation

  公开号：US05051436A1

  公开（公告）日：1991-09-24

  Novel N-acyl- and N-sulfonylbenzo-1,2,3-thiadiazole-7-carboxylic acid amides of formula ##STR1## in which X.sub.1 and X.sub.2 independently of one another are each hydrogen or together 1 to 3 halogen atoms; A is sulfonyl or carbonyl; Y is phenyl or phenyl substituted by C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, halogen, C.sub.1 -C.sub.2 haloalkyl, C.sub.1 -C.sub.2 alkoxycarbonyl, C.sub.1 -C.sub.3 alkanoyloxymethyl, cyano and/or by nitro; R is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.5 alkenyl or C.sub.3 -C.sub.5 alkynyl; and in which, furthermore, the group ##STR2## wherein A.sub.1 is methylene, carbonyl or sulfonyl; X.sub.3 is hydrogen, methyl or halogen; m is 2, 3 or 4; and n is zero, 1 or 2. The novel active ingredients have plant-protecting properties and are suitable especially for the preventive protection of plants against attack by phytopathogenic microorganisms such as fungi, bacteria and viruses.

  式为##STR1##的新型N-酰基和N-磺酰基苯并-1,2,3-噻二唑-7-羧酸酰胺，其中X.sub.1和X.sub.2独立地是氢或1至3个卤素原子；A是磺酰基或羰基；Y是苯基或被C.sub.1-C.sub.2烷基，C.sub.1-C.sub.2烷氧基，卤素，C.sub.1-C.sub.2卤代烷基，C.sub.1-C.sub.2烷氧羰基，C.sub.1-C.sub.3烷酰氧甲基，氰和/或硝基取代的苯基；R是氢，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4卤代烷基，C.sub.3-C.sub.5烯基或C.sub.3-C.sub.5炔基；并且其中，基团##STR2##其中A.sub.1是亚甲基，羰基或磺酰基；X.sub.3是氢，甲基或卤素；m是2、3或4；n是零，1或2。这些新型活性成分具有保护植物的性质，特别适用于预防性保护植物免受植物病原微生物（如真菌、细菌和病毒）的侵害。
• Lipoxygenase genes, promoters, transit peptides and proteins thereof
  申请人：——

  公开号：US20040103453A1

  公开（公告）日：2004-05-27

  This invention describes novel lipoxygenase genes and promoters, transit peptides and proteins derived therefrom. More specifically, this invention describes novel promoters that confer chemically inducible but not wound- or pathogen-inducible expression to an associated nucleotide sequence. The invention further describes peptides capable of targeting and associated protein to plastids and proteins having lipoxygenase activity which can be used to inhibit fungal mycotoxins. The invention also describes recombinant sequences containing such promoter sequences, and/or sequences encoding transit peptides and proteins according to the invention. The said recombinant DNA sequences may be used to create transgenic plants, but especially transgenic plants expressing a nucleotide sequence of interest in response to chemicals but not in response to wounding or pathogens.

  本发明描述了新型的脂氧合酶基因和启动子、转运肽和由此衍生的蛋白质。更具体地，本发明描述了赋予化学诱导但不是伤口或病原体诱导表达与相关核苷酸序列相关的新型启动子。该发明还描述了能够将相关蛋白质定向到质体的肽和具有脂氧合酶活性的蛋白质，可用于抑制真菌毒素。该发明还描述了包含此类启动子序列和/或根据本发明编码转运肽和蛋白质的序列的重组序列。这些重组DNA序列可用于创建转基因植物，尤其是在对化学物质做出反应但不对伤口或病原体做出反应的转基因植物表达感兴趣的核苷酸序列。
• Compositions for protecting plants from diseases
  申请人：Ciba-Geigy Corporation

  公开号：US05229384A1

  公开（公告）日：1993-07-20

  Novel benzo-1,2,3-thiadiazole derivatives of the formula ##STR1## in which; A is --OR.sub.4, --SR.sub.4, --N(R.sub.5)R.sub.6, --N(R.sub.7)--N(R.sub.5)R.sub.6, --O--N.dbd.C(R.sub.8)R.sub.9, --N(R.sub.7)--OR.sub.10, or ##STR2## R.sub.4 is C.sub.1 -C.sub.18 alkyl, C.sub.3 -C.sub.35 alkyl which is interrupted by an oxygen or sulfur atom, C.sub.1 -C.sub.8 alkyl which is substituted by halogen or --COOR.sub.7, C.sub.3 -C.sub.6 alkenyl which is unsubstituted or substituted by halogen, C.sub.3 -C.sub.6 alkinyl which is unsubstituted or substituted by halogen, C.sub.4 -C.sub.7 cycloalkyl which is unsubstituted or substituted by halogen or methyl, an aryl or heterocyclic radical U having not more than 3 heteroatoms O, N and/or S, or a radical U which is linked via an alkylene bridge containing not more than 6 carbon atoms and up to 2 oxygen atoms. The novel active substances have plant protection properties and are particularly suitable for preventive protection of plants against attack by phytopathogenic microorganisms such as fungi, bacteria and viruses.

  本发明涉及一种benzo-1,2,3-噻二唑衍生物，其化学式为##STR1##其中；A为--OR.sub.4、--SR.sub.4、--N(R.sub.5)R.sub.6、--N(R.sub.7)--N(R.sub.5)R.sub.6、--O--N.dbd.C(R.sub.8)R.sub.9、--N(R.sub.7)--OR.sub.10或##STR2##R.sub.4为C.sub.1-C.sub.18烷基、被氧或硫原子中断的C.sub.3-C.sub.35烷基、被卤素或--COOR.sub.7取代的C.sub.1-C.sub.8烷基、未取代或被卤素取代的C.sub.3-C.sub.6烯基、未取代或被卤素取代的C.sub.3-C.sub.6炔基、未取代或被卤素或甲基取代的C.sub.4-C.sub.7环烷基、具有不超过3个杂原子O、N和/或S的芳基或杂环基U，或者通过含有不超过6个碳原子和最多2个氧原子的烷基桥连接的基团U。这种新的活性物质具有植物保护性能，特别适用于预防保护植物免受植物病原微生物（如真菌、细菌和病毒）的攻击。
• Chemically regulatable DNA sequences and genes and uses thereof
  申请人：CIBA-GEIGY AG

  公开号：EP0332104A2

  公开（公告）日：1989-09-13

  The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. Also provided are a novel signal peptide sequence, genes which code for this sequence, and newly identified PR protein genes. The chimeric constructions and transgenic plants and plant tissues may be used in an assay for new chemical regulators.

  本发明提供了能够调节植物或植物组织中相关 DNA 序列转录的化学可调控 DNA 序列、含有此类序列的嵌合结构、含有此类序列和嵌合结构的载体以及含有这些嵌合结构的转基因植物和植物组织。此外，还提供了一种新型信号肽序列、编码该序列的基因以及新鉴定的 PR 蛋白基因。嵌合构建体和转基因植物及植物组织可用于检测新的化学调节剂。
• Transgenic plants expressing cellulolytic enzymes
  申请人：Syngenta Participations AG

  公开号：EP1574580A2

  公开（公告）日：2005-09-14

  The invention provides novel methods of controlling gene expression in plastids, using an inducible, transactivator-mediated system, and plants comprising the novel expression systems. The present invention further describes the production of cellulose-degrading enzymes in plants via the application of genetic engineering techniques. Cellulase coding sequences are fused to promoters active in plants and transformed into the nuclear genome and the chloroplast genome. As cellulases may be toxic to plants, preferred promoters are those that are chemically-inducible. In this manner, expression of the cellulase genes transformed into plants may be chemically induced at an appropriate time. In addition, the expressed cellulases may be targeted to vacuoles or other organelles to alleviate toxicity problems. The present invention finds utility in any industrial process requiring a plentiful supply of cellulases, but particularly finds utility in the conversion of cellulosic biomass to ethanol.

  本发明提供了利用可诱导的转座子介导系统控制质体中基因表达的新型方法，以及包含新型表达系统的植物。本发明进一步描述了通过应用基因工程技术在植物中生产纤维素降解酶。纤维素酶编码序列与在植物中活跃的启动子融合，并转化到核基因组和叶绿体基因组中。由于纤维素酶可能对植物有毒，因此首选化学诱导型启动子。这样，转化到植物中的纤维素酶基因就可以在适当的时候被化学诱导表达。此外，还可将表达的纤维素酶靶向液泡或其他细胞器，以减轻毒性问题。本发明适用于任何需要大量纤维素酶供应的工业过程，但尤其适用于纤维素生物质转化为乙醇的过程。