2-(2-bromobenzyl)-2-methylmalonic acid | 1174193-13-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-(2-bromobenzyl)-2-methylmalonic acid
• 英文别名: 2-[(2-Bromophenyl)methyl]-2-methylpropanedioic acid
• CAS: 1174193-13-5
• 化学式: C₁₁H₁₁BrO₄
• 分子量: 287.11
• InChiKey: QALWQCSPOMZOTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-bromobenzyl)-2-methylmalonic acid 在 氯化亚砜 作用下， 反应 4.0h， 生成
  参考文献：
  名称：

  Desymmetrization of malonamides via an enantioselective intramolecular Buchwald–Hartwig reaction

  摘要：

  A new form of enantioselective nitrogen arylation reaction is described. Beginning with symmetrical alpha-(2-bromobenzyl)malonamides, intramolecular palladium-catalyzed cross-coupling using a catalyst system including 3.3 mol % Pd(OAc)(2) and 6.6 mol % of the chiral biaryl monophosphine (R)-MOP, desymmetrized quinolinone products are obtained in nearly quantitative yields in enantiomeric ratios up to 88:12. This Letter represents a rare example of enantioselective Buchwald-Hartwig reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.133
• 作为产物：
  描述：

  diethyl 2-(2-bromobenzyl)-2-methylmalonate 在 水 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 2-(2-bromobenzyl)-2-methylmalonic acid
  参考文献：
  名称：

  Desymmetrization of malonamides via an enantioselective intramolecular Buchwald–Hartwig reaction

  摘要：

  A new form of enantioselective nitrogen arylation reaction is described. Beginning with symmetrical alpha-(2-bromobenzyl)malonamides, intramolecular palladium-catalyzed cross-coupling using a catalyst system including 3.3 mol % Pd(OAc)(2) and 6.6 mol % of the chiral biaryl monophosphine (R)-MOP, desymmetrized quinolinone products are obtained in nearly quantitative yields in enantiomeric ratios up to 88:12. This Letter represents a rare example of enantioselective Buchwald-Hartwig reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.133

文献信息

• Substituted Metallocene Catalysts
  申请人：ExxonMobile Chemical Patents Inc.

  公开号：US20150025209A1

  公开（公告）日：2015-01-22

  This invention relates to novel bridged a hafnium transition metal metallocene catalyst compounds having two indenyl ligands substituted at the 4 positions with a C 1 to C 10 alkyl, where the 3 positions are hydrogen (assuming the bridge position is counted as the one position) and the bridging atom is carbon or silicon which is incorporated into a cyclic group comprising 3, 4, 5, or 6 silicon and/or carbon atoms that make up the cyclic ring.

  本发明涉及一种新型的桥式铪过渡金属茂金属催化剂化合物，其具有两个4位被C1到C10烷基取代的茚基配体，其中3位是氢（假设桥接位置被计为1位），桥接原子是碳或硅，其被并入一个包括3、4、5或6个硅和/或碳原子的环状基团中，这些原子组成环状环。
• Hybrid supported metallocene catalyst, and polyolefin resin having excellent processability and using same
  申请人：HANWHA CHEMICAL CORPORATION

  公开号：US11248067B2

  公开（公告）日：2022-02-15

  The present invention relates to a hybrid supported metallocene catalyst including at least first metallocene compound, at least one second metallocene compound, at least one cocatalyst compound, and a carrier, a preparation method therefor, and a polyolefin resin polymerized in the presence of the catalyst, wherein the second metallocene compound is a compound of a bridged structure having a ligand of an asymmetric structure, and the polyolefin resin has a density of 0.910 g/cm3 to 0.960 g/cm3, a molecular weight density in a unimodal distribution of 3 to 5, a melt index of 0.05 to 100 at 2.16 kg, and a melt flow rate of 20 to 40.

  本发明涉及一种包括至少第一茂金属化合物、至少一种第二茂金属化合物、至少一种助催化剂化合物和载体的杂化支撑茂金属催化剂、其制备方法以及在该催化剂存在下聚合的聚烯烃树脂，其中第二茂金属化合物是具有不对称结构配位体的桥接结构的化合物，聚烯烃树脂的密度为0.910 g/cm3 至 0.960 g/cm3，单峰分布的分子量密度为 3 至 5，熔融指数在 2.16 kg 时为 0.05 至 100，熔体流动速率为 20 至 40。
• WO2007/70040
  申请人：——

  公开号：——

  公开（公告）日：——
• WO2007/70041
  申请人：——

  公开号：——

  公开（公告）日：——
• SUBSTITUTED METALLOCENE CATALYSTS
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：EP3022234B1

  公开（公告）日：2018-12-26