(R)-N-[[3-[3-fluoro-4-(N-piperazinyl)]-phenyl]-2-oxo-5-oxazolidinyl]methylalcohol | 216869-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-N-[[3-[3-fluoro-4-(N-piperazinyl)]-phenyl]-2-oxo-5-oxazolidinyl]methylalcohol
• 英文别名: (R)-3-(3-fluoro-4-(piperazin-1-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one；(5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one
• CAS: 216869-31-7
• 化学式: C₁₄H₁₈FN₃O₃
• 分子量: 295.314
• InChiKey: DEPCOGNKPYZDHS-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  65
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (R)-N-[[3-[3-fluoro-4-(N-piperazinyl)]-phenyl]-2-oxo-5-oxazolidinyl]methylalcohol 、 5-硝基糠醛 在 三乙酰氧基硼氢化钠 作用下， 以 四氢呋喃 为溶剂， 生成 (5R)-3-[3-fluoro-4-[4-[(5-nitrofuran-2-yl)methyl]piperazin-1-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Synthesis and biological activity of novel oxazolidinones

  摘要：

  A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized. Antibacterial activity of the compounds against a number of sensitive and resistant bacteria showed promising results. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.054
• 作为产物：
  描述：

  (R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methanol 在 palladium/active carbon 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 2.83h， 生成 (R)-N-[[3-[3-fluoro-4-(N-piperazinyl)]-phenyl]-2-oxo-5-oxazolidinyl]methylalcohol
  参考文献：
  名称：

  Oxazolidinone antibacterial agents having a thiocarbonyl functionality

  摘要：

  本发明提供了式1化合物： 或药物可接受的盐，其中A，G和R1如权利要求中所定义，它们是抗菌剂。

  公开号：

  US06342513B1

文献信息

• Derivatives of oxazolidinones as antibacterial agents
  申请人：——

  公开号：US20040147545A1

  公开（公告）日：2004-07-29

  This invention discloses new fluorquinolonic derivatives of oxazolidinones of general formula (I) and processes for obtaining them, the corresponding pharmaceutical compositions and use thereof for manufacturing a medicament for the treatment of microbial infections. These new compounds are useful as antibacterial agents. Formula (I). Furthermore phenalen-type compounds according to general formula (II) are disclosed. Formula (II).

  本发明公开了通式(I)的噁唑烷酮的新氟喹诺酮衍生物、获得它们的工艺、相应的药物组合物及其用于制造治疗微生物感染的药物。这些新化合物可用作抗菌剂。式 (I)。此外，还公开了通式（II）的苯茚类化合物。式 (II).
• [EN] ANTIINFECTVE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES ANTI-INFECTIEUX, PROCESSUS DE PREPARATION DE CES COMPOSES ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：——

  公开号：WO2003082864A3

  公开（公告）日：2003-11-13
• NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIAL AGENTS
  申请人：LABORATORIOS VITA, S.A.

  公开号：EP1401834A1

  公开（公告）日：2004-03-31
• [EN] NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIAL AGENTS<br/>[FR] NOUVEAUX DERIVES D'OXAZOLIDINONES EN TANT QU'AGENTS ANTIBACTERIENS
  申请人：VITA INVEST SA

  公开号：WO2003002560A1

  公开（公告）日：2003-01-09

  This invention discloses new fluorquinolonic derivatives of oxazolidinones of general formula (I) and processes for otaining them, the corresponding pharmaceutical compositions and use thereof for manufacturing a medicament for the treatment of microbial infections. These new compounds are useful as antibacterial agents. Formula (I). Furthermore phenalen-type compounds according to general formula (II) are disclosed. Formula (II).
• Oxazolidinone antibacterial agents having a thiocarbonyl functionality
  申请人：Pharmacia and Upjohn Company

  公开号：US06342513B1

  公开（公告）日：2002-01-29

  The present invention provides compounds of Formula 1: or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.

  本发明提供了式1化合物： 或药物可接受的盐，其中A，G和R1如权利要求中所定义，它们是抗菌剂。