bis(1,10-phenanthroline)(dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(II) | 148409-03-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: bis(1,10-phenanthroline)(dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(II)
• 英文别名: [Ru(phen)₂(dppz)]²⁺；1,10-Phenanthroline;quinoxalino[2,3-f][1,10]phenanthroline;ruthenium(2+)
• CAS: 148409-03-4；148409-04-5；92543-42-5
• 化学式: C₄₂H₂₆N₈Ru
• 分子量: 743.792
• InChiKey: ZUVQSBBMSWLSDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.44
• 重原子数：
  51
• 可旋转键数：
  0
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  Ru(phen)₂Cl₂ 、 二吡啶并[3,2-a:2',3'-c]吩嗪 以 乙醇 、 水 为溶剂， 生成 bis(1,10-phenanthroline)(dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(II)
  参考文献：
  名称：

  Methods to Explore Cellular Uptake of Ruthenium Complexes

  摘要：

  The cellular uptake of a series of dipyridophenazine (dppz) complexes of Ru(II) was examined by flow cytometry. The complexes, owing to their facile synthesis, stability, and luminescence, provide a route to compare and contrast systematically factors governing cellular entry. Substituting the ancillary ligands in the dppz complexes of Ru(II) permits variation in the overall complex charge, size, and hydrophobicity. In HeLa cells, cellular uptake appears to be facilitated by the lipophilic 4,7-diphenyl-1,10-phenanthroline (DIP) ligand. Despite the large size of Ru(DIP)2dppz2+ (20 Å diameter), this complex is readily transported inside the cell compared to smaller and more hydrophilic complexes such as Ru(bpy)2dppz2+. Accumulation in the cellular interior is confirmed by confocal microscopy.

  DOI：

  10.1021/ja0677564

文献信息

• Enantiomeric Separations of Ruthenium (II) Polypyridyl Complexes Using HPLC With Cyclofructan Chiral Stationary Phases
  作者：Yang Shu、Zachary S. Breitbach、Milan K. Dissanayake、Sirantha Perera、Joseph M. Aslan、Nagham Alatrash、Frederick M. MacDonnell、Daniel W. Armstrong

  DOI：10.1002/chir.22389

  日期：2015.1

  The enantiomeric separation of 21 ruthenium (II) polypyridyl complexes was achieved with a novel class of cyclofructan‐based chiral stationary phases (CSPs) in the polar organic mode. Aromatic derivatives on the chiral selectors proved to be essential for enantioselectivity. The R‐napthylethyl carbamate functionalized cyclofructan 6 (LARIHC CF6‐RN) column proved to be the most effective overall, while

  通过一类新型的基于环果聚糖的手性固定相（CSP）以极性有机模式实现了21个钌（II）聚吡啶基配合物的对映体分离。经证明，手性选择剂上的芳族衍生物对于对映体选择性至关重要。氨基甲酸R-萘甲酸乙基酯官能化的环果聚糖6（LARIHC CF6-RN）色谱柱被认为是最有效的色谱柱，而氨基甲酸二甲基苯基酯环果聚糖7（LARIHC CF7-DMP）具有互补选择性。酸和碱添加剂的组合对于最佳分离是必要的。保留因子VS 。乙腈/甲醇比率图显示了U形保留曲线，表明在不同极性有机溶剂的组成上会发生不同的相互作用。分离结果表明，在极性有机模式下，π-π相互作用，空间效应和氢键有助于钌（II）聚吡啶基配合物与环果聚糖手性固定相的对映体分离。手性27：64–70，2015。©2014 Wiley Periodicals，Inc.
• Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Λ‐[Ru(phen)2phi]2+
  作者：Tayler D. Prieto Otoya、Kane T. McQuaid、Joseph Hennessy、Georgia Menounou、Alex Gibney、Neil G. Paterson、David J. Cardin、Andrew Kellett、Christine J. Cardin

  DOI：10.1002/anie.202318863

  日期：2024.3.22

  Major changes—the crystallisation of a junction forming DNA decamer with Λ-[Ru(phen)2phi]2+ shows three different sequence-selective binding modes, and displacement of Sr2+ from the minor groove to the interhelical space.

  主要变化——与Λ-[Ru(phen) 2 phi] 2+形成DNA十聚体的结点的结晶显示出三种不同的序列选择性结合模式，以及Sr 2+从小沟到螺旋间隙的位移。