nonylhydrazine | 2656-74-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: nonylhydrazine
• 英文别名: Nonylhydrazin；Diazaundecane
• CAS: 2656-74-8
• 化学式: C₉H₂₂N₂
• 分子量: 158.287
• InChiKey: IDIXOSREORKJTN-UHFFFAOYSA-N

物化性质

• 沸点：
  110-114 °C(Press: 11 Torr)
• 密度：
  0.834±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  五氟丙酸甲酯 、 nonylhydrazine 以 甲醇 为溶剂， 反应 4.0h， 以67%的产率得到1-nonyl-2-pentafluoropropionylhydrazine
  参考文献：
  名称：

  酰肼和烷基酰肼或氟化链烷羧酸的质谱

  摘要：

  已经研究了链烷羧酸的酰肼和烷基酰肼的电子碰撞诱导质谱裂解的主要途径。建立了氟化酰基和烃基结构对离解方式的影响。

  DOI：

  10.1016/s0022-1139(00)85071-x

文献信息

• AMINO ACID AMIDES OF PHENOXYBUTYRIC ACID DERIVATIVES
  申请人：LALEZARI IRAJ

  公开号：US20120232120A1

  公开（公告）日：2012-09-13

  A compound of the formula: where X is phenyl substituted at the 3, 4 and 5 positions with R1, R2 or R3 which are selected from hydrogen, chloro, lower alkyl of 1 to 5 carbons, phenoxy, phenyl, naphthyl, or phenyl (lower) alkyl where the lower alkyl group has 1-5 carbon atoms and m is 0 or 1; Y is —CONH— or —NHCONH— where the nitrogen atoms are unsubstituted or substituted with other phenoxyisobutyric acid derivatives, or the residue of a phenoxyisobutyric acid and n is 0 or 1; Z is unsubstituted phenyl when m is 1 and n is 1; when Y is 0, X is 0; Z is also substituted.

  式的化合物： 其中X是苯基，取代在3、4和5位与R1、R2或R3，它们从氢、氯、1至5个碳原子的低烷基、苯氧基、苯基、萘基或苯基（低）烷基中选择，其中低烷基基团有1-5个碳原子，m为0或1；Y为—CONH—或—NHCONH—，其中氮原子未取代或取代为其他苯氧异丁酸衍生物，或苯氧异丁酸的残基，n为0或1；当m为1且n为1时，Z为未取代的苯基；当Y为0时，X为0；Z也被取代。
• [EN] COMPOSITIONS AND METHODS FOR THERAPY OF PROSTATE CANCER USING DRUG COMBINATIONS TO TARGET POLYAMINE BIOSYNTHESIS AND RELATED PATHWAYS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER DE LA PROSTATE UTILISANT DES COMBINAISONS DE MÉDICAMENTS POUR CIBLER LA BIOSYNTHÈSE DES POLYAMINES ET LES VOIES ASSOCIÉES
  申请人：HEALTH RESEARCH INC

  公开号：WO2016187183A1

  公开（公告）日：2016-11-24

  Provided are compositions and methods for treating prostate conditions. The methods involve administering to an individual in need thereof a composition that contains i) an inhibitor of methionine salvage pathway in prostate of the individual and ii) a polyamine analogue. The methods are for use in individuals who have been diagnosed with, or are suspected of having or at risk for developing androgen sensitive prostate cancer (AS-CaP), or Castration recurrent CaP (CR-CaP), or benign prostate hyperplasia (BPH). The disclosure includes use of inhibitors of methylthioadenosine phosphorylase (MTAP), and a polyamine analog that upregulates polyamine catabolism by increasing spermidine/spermine Nl -acetyl transferase (SAT1) activity, such as methylthio-DADMe-Immucillin (MTDIA), andl),N(11)-bisethylnorspermine (BENSpm), respectively. Pharmaceutical formulations that contain a combination of the inhibitor of the methionine salvage pathway and a polyamine analogue are included, as are kits that contain such agents.

  提供了用于治疗前列腺疾病的组合物和方法。这些方法涉及向需要的个体施用一种含有i) 抑制前列腺中蛋氨酸拯救途径的抑制剂和ii) 多胺类似物的组合物。这些方法适用于被诊断出患有、或被怀疑患有或有发展为雄激素敏感的前列腺癌（AS-CaP）、或去势复发型前列腺癌（CR-CaP）、或良性前列腺增生（BPH）的个体。该公开包括使用甲硫氨酸腺苷磷酸化酶（MTAP）的抑制剂，以及通过增加精胺/精氨酸Nl-乙酰转移酶（SAT1）活性来上调多胺代谢的多胺类似物，如甲硫-DADMe-Immucillin（MTDIA）和N(11)-双乙基诺精胺（BENSpm）。包含抑制蛋氨酸拯救途径的抑制剂和多胺类似物的药物配方被纳入，还包括包含这些药剂的试剂盒。
• DERIVATIVES OF PHENOXYISOBUTYRIC ACID
  申请人：FABRICANT Jill S.

  公开号：US20140371316A1

  公开（公告）日：2014-12-18

  The present invention provides a process for the synthesis of substituted phenoxymethylpropiomc acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).

  本发明提供了一种合成取代苯氧甲基丙烯酸及相关化合物的方法。这些化合物对抑制AGEs（高级糖基化终产物）的形成很有用。
• Novel phenoxyisobutyric acid compounds and methods for synthesis
  申请人：Lalezari Iraj

  公开号：US20120071502A1

  公开（公告）日：2012-03-22

  The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).

  本发明提供了一种合成取代苯氧甲基丙酸及相关化合物的方法。这些化合物可用于抑制AGEs（高级糖基化终产物）的形成。
• [EN] METHODS AND COMPOSITIONS FOR TREATING MOOD DISORDER<br/>[FR] COMPOSITIONS ET METHODES DE TRAITEMENT DES TROUBLES DE L'HUMEUR
  申请人：WITTLIN WILLIAM A

  公开号：WO2005120523A1

  公开（公告）日：2005-12-22

  The invention relates to compositions and methods for treating mood spectrum disorder. The compositions relate to novel combinations and formulations of pharmaceutical compounds for treatment of mood spectrum disorders. The methods provide for use of the compounds provided herein for the treatment of mood spectrum disorders in addition to the use of mood screens for diagnosing a patient.

  本发明涉及用于治疗情绪谱系障碍的组合物和方法。所述组合物涉及用于治疗情绪谱系障碍的新型药物化合物的组合和制剂。所述方法提供了使用本文提供的化合物治疗情绪谱系障碍的方法，以及使用情绪筛查诊断患者的方法。