trans-3,3-dimethyl-2-phenylcyclopropanamine | 882188-78-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: trans-3,3-dimethyl-2-phenylcyclopropanamine
• 英文别名: trans-2,2-Dimethyl-3-phenyl-cyclopropylamin；rac-trans-2,2-dimethyl-3-phenyl-cyclopropylamine；(1R,3S)-2,2-dimethyl-3-phenylcyclopropan-1-amine
• CAS: 882188-78-5
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: NFISWOCMUKKIGN-NXEZZACHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  trans-3,3-dimethyl-2-phenylcyclopropanamine 生成 trans-1-Dimethylamino-2,2-dimethyl-3-phenyl-cyclopropan
  参考文献：
  名称：

  Smejkal,J.; Farkas,J., Collection of Czechoslovak Chemical Communications, 1963, vol. 28, p. 404 - 410

  摘要：

  DOI：
• 作为产物：
  描述：

  (+/-)-2,2-dimethyl-3t-phenyl-cyclopropane-r-carbonyl chloride 在 sodium azide 作用下， 生成 trans-3,3-dimethyl-2-phenylcyclopropanamine
  参考文献：
  名称：

  Smejkal,J.; Farkas,J., Collection of Czechoslovak Chemical Communications, 1963, vol. 28, p. 404 - 410

  摘要：

  DOI：

文献信息

• Cyclopropyl aryl amide derivatives and uses thereof
  申请人：Bois Daisy Joe Du

  公开号：US20090093525A1

  公开（公告）日：2009-04-09

  Compounds of the formula: wherein Ar 1 , Ar 2 , R 1 and R 2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.

  其中Ar1、Ar2、R1和R2的化合物的公式。还提供了药物组合物、使用方法和制备所述化合物的方法。
• The <i>N</i>-Cyclopropylimine-1-pyrroline Photorearrangement as a Synthetic Tool:  Scope and Limitations
  作者：Alberto Soldevilla、Diego Sampedro、Pedro J. Campos、Miguel A. Rodríguez

  DOI：10.1021/jo050871x

  日期：2005.8.1

  [GRAPHICS]The scope and limitations of the photorearrangement of N-cyclopropylimines to 1-pyrrolines are presented. The influence on the reactivity of different substituents throughout the cyclopropane ring and at the iminic position of the N-cyclopropylimine structure is discussed. The observed effects are interpreted from computational studies. The principal findings relate to (1) the enhanced reactivity of 1-substituted compounds toward rearrangement, (2) the lack of reactivity of crowded cyclopropanes, and (3) the high chemoselectivity of the process.
• CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2207540B1

  公开（公告）日：2014-02-26
• US7723391B2
  申请人：——

  公开号：US7723391B2

  公开（公告）日：2010-05-25
• [EN] CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE CYCLOPROPYL ARYL AMIDES ET LEURS UTILISATIONS
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009043784A1

  公开（公告）日：2009-04-09

  Compounds of the formula (I) wherein Ar1, Ar2, R1 and R2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.