(biotin)2DAE | 157720-48-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: (biotin)2DAE
• 英文别名: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethyl]pentanamide
• CAS: 157720-48-4
• 化学式: C₂₂H₃₆N₆O₄S₂
• 分子量: 512.698
• InChiKey: HOHQXYDEYPNMKQ-IGVQRDAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  191
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (+)-生物素 4-硝基苯酯 、 乙二胺 以 N,N-二甲基甲酰胺 为溶剂， 以58%的产率得到(biotin)2DAE
  参考文献：
  名称：

  Self-Assembled Morphologies from C₂- and C₃-Symmetric Biotin Conjugates

  摘要：

  Synthesis and characterization of C-2- and C-3-symmetric D-biotin conjugates has been realized, followed by the investigation of solution state self-assembly behavior of these conjugates by various microscopy techniques. Interestingly, the C-2-symmetric conjugate affords the formation of fibrous structures, while the C-3-symmetric conjugate reveals the formation of marigold flower-like spherical morphologies.

  DOI：

  10.1021/jo100881r

文献信息

• Biotin amides, a process for their preparation and therapeutical compositions containing them as the active principles for the treatment of diabetes and relative complicating diseases
  申请人：LIFEGROUP S.p.A.

  公开号：EP0590563A1

  公开（公告）日：1994-04-06

  Biotin amides, a process for their preparation and therapeutical compositions containing them as the active principles for the treatment of insulin-independent and insulin-dependent diabetes and relative complicating diseases, such as peripheral neuropathies, chronic and invalidating pathologies.

  生物素酰胺、生物素酰胺的制备方法以及含有生物素酰胺作为活性成分的治疗组合物，用于治疗胰岛素依赖型和胰岛素依赖型糖尿病及相关并发症，如周围神经病、慢性病和致残性疾病。
• Self-Assembled Morphologies from <i>C</i>₂- and <i>C</i>₃-Symmetric Biotin Conjugates
  作者：K. B. Joshi、K. Vijaya Krishna、Sandeep Verma

  DOI：10.1021/jo100881r

  日期：2010.6.18

  Synthesis and characterization of C-2- and C-3-symmetric D-biotin conjugates has been realized, followed by the investigation of solution state self-assembly behavior of these conjugates by various microscopy techniques. Interestingly, the C-2-symmetric conjugate affords the formation of fibrous structures, while the C-3-symmetric conjugate reveals the formation of marigold flower-like spherical morphologies.