N-(3-dimethylaminopropyl)-N-propylamine | 19475-28-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(3-dimethylaminopropyl)-N-propylamine
• 英文别名: propyl-(3-N’,N’-dimethylaminopropyl)amine；N¹,N¹-dimethyl-N³-propylpropane-1,3-diamine；N,N-Dimethyl-N'-propyl-trimethylendiamin；N,N-Dimethyl-N'-propyl-1,3-propanediamine；Propyl-(3-N',N'-dimethylaminopropyl)amine；[3-(Dimethylamino)propyl](propyl)amine；N',N'-dimethyl-N-propylpropane-1,3-diamine
• CAS: 19475-28-6
• 化学式: C₈H₂₀N₂
• mdl: MFCD11146411
• 分子量: 144.26
• InChiKey: LVCAUABGOWBVQM-UHFFFAOYSA-N

物化性质

• 沸点：
  102-103 °C(Press: 75 Torr)
• 密度：
  0.816±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险类别：
  8,3
• 危险性防范说明：
  P210,P233,P240,P241,P242,P243,P260,P264,P280,P301+P330+P331,P303+P361+P353,P304+P340,P305+P351+P338,P310,P363,P370+P378,P403+P235,P405,P501
• 危险品运输编号：
  2734
• 危险性描述：
  H225,H314
• 包装等级：
  II

反应信息

• 作为反应物：
  描述：

  N-(3-dimethylaminopropyl)-N-propylamine 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-Methyl-6-propyl-8-amino-2,6-diaza-octan
  参考文献：
  名称：

  Somin,I.N., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, # 4, p. 122 - 125

  摘要：

  DOI：
• 作为产物：
  描述：

  正丙胺 、 N,N-二甲基-3-氯丙胺 生成 N-(3-dimethylaminopropyl)-N-propylamine
  参考文献：
  名称：

  Somin,I.N., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, # 4, p. 122 - 125

  摘要：

  DOI：

文献信息

• NUCLEIC ACID BINDING DYES AND USES THEREFOR
  申请人：McDougall Mark

  公开号：US20100233710A1

  公开（公告）日：2010-09-16

  The invention provides novel compounds and compositions of Formulas I and II, as well as methods of using them. The compounds can be used, for example, to quantify an amount of double stranded DNA in a sample subjected to nucleic acid amplification, or for real time monitoring of a nucleic acid amplification reaction. The compounds can be provided in a kit, for example, with other reagents and instructions for using the compounds and reagents.

  这项发明提供了Formula I和Formula II的新化合物和组合物，以及使用它们的方法。这些化合物可以用于例如，在经过核酸扩增的样本中定量双链DNA的数量，或者用于实时监测核酸扩增反应。这些化合物可以作为一种试剂盒的一部分提供，例如，与其他试剂和使用这些化合物和试剂的说明书一起。
• Nucleic acid binding dyes and uses therefor
  申请人：PROMEGA CORPORATION

  公开号：US09206474B2

  公开（公告）日：2015-12-08

  The invention provides novel compounds and compositions of Formulas I and II, as well as methods of using them. The compounds can be used, for example, to quantify an amount of double stranded DNA in a sample subjected to nucleic acid amplification, or for real time monitoring of a nucleic acid amplification reaction. The compounds can be provided in a kit, for example, with other reagents and instructions for using the compounds and reagents.

  这项发明提供了Formula I和Formula II的新化合物和组合物，以及它们的使用方法。这些化合物可以用于在经过核酸扩增的样本中定量双链DNA的数量，或用于实时监测核酸扩增反应。这些化合物可以作为试剂盒的一部分提供，例如，与其他试剂和使用这些化合物和试剂的说明一起。
• [EN] ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS<br/>[FR] COMPOSÉS SE LIANT À L'ASGPR POUR LA DÉGRADATION DE PROTÉINES EXTRACELLULAIRES
  申请人：AVILAR THERAPEUTICS INC

  公开号：WO2021155317A1

  公开（公告）日：2021-08-05

  Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

  描述了将一个与外细胞蛋白结合配体结合的阿斯利康糖蛋白受体（ASGPR）结合配体的化合物和组合物，用于选择性降解体内靶外细胞蛋白以治疗由外细胞蛋白介导的疾病。
• Novel, Rapid, and Inexpensive Cell-Based Quantification of Antimalarial Drug Efficacy
  作者：Tyler N. Bennett、Michelle Paguio、Bojana Gligorijevic、Clement Seudieu、Andrew D. Kosar、Eugene Davidson、Paul D. Roepe

  DOI：10.1128/aac.48.5.1807-1810.2004

  日期：2004.5

  We report on the development of a new SYBR Green I-based plate assay for analyzing the activities of antimalarial drugs against intraerythrocytic Plasmodium falciparum . This assay is considerably faster, less labor-intensive, and less expensive than conventional radiotracer (e.g., [ ³ H]hypoxanthine and [ ³ H]ethanolamine)-based assays or P. falciparum lactate dehydrogenase activity-based assays. The assay significantly improves the pace at which antimalarial drug discovery efforts may proceed.

  摘要 我们报告了一种基于 SYBR Green I 的新型平板检测方法的开发情况，该方法可用于分析抗疟药物对红细胞内 恶性疟原虫 .与传统的放射性示踪剂（如[3 3 H]次黄嘌呤和[3 3 3H]次黄嘌呤和[3H]乙醇胺）或 恶性疟原虫 乳酸脱氢酶活性的检测方法。该检测方法大大提高了抗疟药物研发工作的速度。
• 1,3,5-Substituted Phenyl Derivative Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
  申请人：Barrow C. James

  公开号：US20070244119A1

  公开（公告）日：2007-10-18

  The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及一类1,3,5-苯基取代衍生物化合物，它们是β-分泌酶酶的抑制剂，可用于治疗β-分泌酶酶参与的疾病，如阿尔茨海默病。本发明还涉及包含这些化合物的制药组合物，以及这些化合物和组合物在治疗β-分泌酶酶参与的疾病中的用途。