{(1R,2R)-cyclohexane-1,2-diamine}dibromidoplatinum | 67225-24-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: {(1R,2R)-cyclohexane-1,2-diamine}dibromidoplatinum
• 英文别名: cis-dibromo(1,2-diaminocyclohexane)platinum(II)；(1S,2R)-cyclohexane-1,2-diamine;dibromoplatinum
• CAS: 67225-24-5
• 化学式: C₆H₁₄Br₂N₂Pt
• 分子量: 469.079
• InChiKey: USYRFUJAOPPSHP-UOXVPMNTSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  tris[cis-dichloro(1,2-diaminocyclohexane)platinum(II)]hydrate 、 potassium bromide 在 silver nitrate 作用下， 以 水 为溶剂， 生成 {(1R,2R)-cyclohexane-1,2-diamine}dibromidoplatinum
  参考文献：
  名称：

  Tris[cis-dichloro(1,2-diaminocyclohexane)-platinum(II)] hydrate and cis-dibromo(1,2-diaminocyclohexane)platinum(II)

  摘要：

  DOI：

  10.1107/s0567740881002161

文献信息

• Chlorido and bromido oxaliplatin analogues as potential agents for CRC treatment: Solution behavior, protein binding and cytotoxicity evaluation
  作者：Tiziano Marzo、Alessandro Pratesi、Damiano Cirri、Serena Pillozzi、Giulia Petroni、Annalisa Guerri、Annarosa Arcangeli、Luigi Messori、Chiara Gabbiani

  DOI：10.1016/j.ica.2017.05.067

  日期：2018.1

  Despite the widespread use of platinum drugs in the treatment of colorectal cancer (CRC), due to the heavy side effects and to intrinsic or acquired Pt resistance, new and more efficient drugs are urgently needed. Starting from the encouraging results obtained for the complex PtI2(DACH), we summarise here our recent advances, reporting data on the synthesis and the chemical and biological features of two oxaliplatin analogues i.e. PtBr2(DACH) and PtCl2(DACH). The comparative approach of these studies reveals how these analogues possess interesting and differential pharmacological properties as well as some peculiar features that may be conveniently exploited to shed light in the mechanistic aspects involved in the pharmacological action of the parent drug oxaliplatin. Furthermore, these findings may inspire the design of more effective Pt-based anticancer drugs to be used in CRC treatment. (C) 2017 Elsevier B.V. All rights reserved.
• Tris[cis-dichloro(1,2-diaminocyclohexane)-platinum(II)] hydrate and cis-dibromo(1,2-diaminocyclohexane)platinum(II)
  作者：C. J. L. Lock、P. Pilon

  DOI：10.1107/s0567740881002161

  日期：1981.1.15