1,1'-(dibenzo[b,d]furan-2,8-diyl)bis(2-bromoethanone) | 1393734-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 1,1'-(dibenzo[b,d]furan-2,8-diyl)bis(2-bromoethanone)
• 英文别名: 2-Bromo-1-[8-(2-bromoacetyl)dibenzofuran-2-yl]ethanone；2-bromo-1-[8-(2-bromoacetyl)dibenzofuran-2-yl]ethanone
• CAS: 1393734-82-1
• 化学式: C₁₆H₁₀Br₂O₃
• 分子量: 410.062
• InChiKey: MBTLEKDJFQPRBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1'-(dibenzo[b,d]furan-2,8-diyl)bis(2-bromoethanone) 在 碳酸氢钠 、 三氟乙酸 、 potassium hydroxide 、 三氯氧磷 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 11.83h， 生成 3,3'-(dibenzo[b,d]furan-2,8-diyl)bis(4,6-dimethoxy-1H-indole-7-carbaldehyde)
  参考文献：
  名称：

  Synthesis of new di-(3-indolyl)arenes

  摘要：

  1,4-Di-(3-indolyl)benzene 6 and 2,8-di-(3-indolyl)dibenzofuran 12 were synthesized from 1,4-diacetylbenzene and 2,8-diacetyldibenzofuran, respectively, via indole synthetic strategies. Investigation into the acid-catalysed formation of macrocyclic systems from these di-(3-indolyl)arenes led to the development of the 18-membered macrocycle 14 from the diindolylbenzene 6, which was capable of undergoing complexation with nickel(II) ions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.074
• 作为产物：
  描述：

  1-(8-乙酰基二苯并呋喃-2-基)乙酮 在 溴 、 溶剂黄146 作用下， 反应 4.0h， 以54%的产率得到1,1'-(dibenzo[b,d]furan-2,8-diyl)bis(2-bromoethanone)
  参考文献：
  名称：

  Synthesis of new di-(3-indolyl)arenes

  摘要：

  1,4-Di-(3-indolyl)benzene 6 and 2,8-di-(3-indolyl)dibenzofuran 12 were synthesized from 1,4-diacetylbenzene and 2,8-diacetyldibenzofuran, respectively, via indole synthetic strategies. Investigation into the acid-catalysed formation of macrocyclic systems from these di-(3-indolyl)arenes led to the development of the 18-membered macrocycle 14 from the diindolylbenzene 6, which was capable of undergoing complexation with nickel(II) ions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.074

文献信息

• Synthesis of new di-(3-indolyl)arenes
  作者：Ibrahim F. Sengul、Kasey Wood、Paul K. Bowyer、Mohan Bhadbhade、Rui Chen、Naresh Kumar、David StC. Black

  DOI：10.1016/j.tet.2012.06.074

  日期：2012.9

  1,4-Di-(3-indolyl)benzene 6 and 2,8-di-(3-indolyl)dibenzofuran 12 were synthesized from 1,4-diacetylbenzene and 2,8-diacetyldibenzofuran, respectively, via indole synthetic strategies. Investigation into the acid-catalysed formation of macrocyclic systems from these di-(3-indolyl)arenes led to the development of the 18-membered macrocycle 14 from the diindolylbenzene 6, which was capable of undergoing complexation with nickel(II) ions. (C) 2012 Elsevier Ltd. All rights reserved.