(perfluoro)N,N-diethyl-n-hexylamine | 52011-01-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (perfluoro)N,N-diethyl-n-hexylamine
• 英文别名: perfluoro(diethyl-n-hexylamine)；perfluoro(diethylhexylamine)；1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-N,N-bis(1,1,2,2,2-pentafluoroethyl)hexan-1-amine
• CAS: 52011-01-5
• 化学式: C₁₀F₂₃N
• 分子量: 571.08
• InChiKey: XDJOUWJLZAWHSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  24

反应信息

• 作为产物：
  描述：

  N,N-二乙基-1-己胺 生成 (perfluoro)N,N-diethyl-n-hexylamine
  参考文献：
  名称：

  Plashkin,V.S. et al., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, p. 2546 - 2551

  摘要：

  DOI：

文献信息

• Electrochemical fluorinatior of some cyclic tertiary amines
  作者：L. Conte、C. Fraccaro、M. Napoli、M. Mistrorigo

  DOI：10.1016/s0022-1139(00)85068-x

  日期：1986.12

  Electrochemical fluorination of N,N-diethylcyclohexylamine and N-ethyldicyclohexylamine gave the corresponding F-amines together with several other compounds arising from incomplete fluorination and fragmentation reactions. In the case of N,N-diethylcyclohexylamine yields of 51–52% were obtained and most of the reaction products were isolated and identified. With N-ethyldicyclohexylamine a lower yield

  N，N-二乙基环己胺和N-乙基二环己胺的电化学氟化反应产生了相应的F-胺，以及由于氟化和裂解反应不完全而产生的其他几种化合物。对于N，N-二乙基环己胺，产率为51–52％，大多数反应产物均已分离和鉴定。用N-乙基二环己基胺观察到较低的收率（16％）。所得的反应混合物太复杂而无法鉴定其成分。对反应机理进行了评论，并报告了已鉴定化合物的NMR和IR数据。
• Perfusate for preserving organ to be transplanted and preserving method
  申请人：The Green Cross Corporation

  公开号：EP0033402A1

  公开（公告）日：1981-08-12

  An organ to be transplanted, such as a kidney, can effectively be preserved for an increased period of time by perfusion using a perfusate which is made of a Ringer's solution modified by increasing its potassium ion content to 8-20 meq/liter with a stably emulsified perfluorocarbon compound and dissolved albumin. A preferred concentration of the perfluorocarbon compound, for example perfluorodecalin, is 7.5 to 12.5%(W/V) and that of albumin is 1-8%(W/V) based on the perfusate.

  灌注液是由林格氏溶液改良而成，改良后的林格氏溶液将钾离子含量提高到 8-20 meq/升，并加入了稳定乳化的全氟碳化合物和溶解的白蛋白。全氟碳化合物（例如全氟萘烷）的优选浓度为 7.5-12.5%(W/V)，白蛋白的优选浓度为灌流液的 1-8%(W/V)。
• Process for rapid thawing and storage of frozen fluorocarbon emulsion, and resultant product
  申请人：ALPHA THERAPEUTIC CORPORATION

  公开号：EP0548601A1

  公开（公告）日：1993-06-30

  A method for rapidly preparing a frozen fluorocarbon emulsion for administration without degradation and having an extended shelf life is disclosed.

  本发明公开了一种快速制备冷冻碳氟化合物乳剂的方法，该乳剂可在不降解的情况下给药，并具有较长的保质期。
• Oxygen-containing ophthalmic composition
  申请人：——

  公开号：US20020164379A1

  公开（公告）日：2002-11-07

  An oxygen-rich ophthalmic composition characterized in that it comprises oxygen and/or oxygen donor, wherein the amount of oxygen and/or oxygen contained in oxygen donor is 10 mg or above per liter of the ophthalmic composition, or the content of oxygen is at least 90% of the saturated dissolved oxygen, which composition is useful in prevention, alleviation, or treatment of ocular diseases, especially corneal diseases or disorders.

  一种富氧眼科组合物，其特征在于它包含氧气和/或供氧体，其中每升眼科组合物中氧气和/或供氧体所含的氧气量为 10 毫克或以上，或者氧气含量至少为饱和溶解氧的 90%，该组合物可用于预防、缓解或治疗眼部疾病，尤其是角膜疾病或失调。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.9, 9, page 159 - 180
  作者：

  DOI：——

  日期：——