(6-hydroxy-1,2,3,4-tetrahydro-napthalen-2-yl)-acetic acid ethyl ester | 164148-43-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (6-hydroxy-1,2,3,4-tetrahydro-napthalen-2-yl)-acetic acid ethyl ester
• 英文别名: ethyl 2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate
• CAS: 164148-43-0
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: HKOJAUZVTOHJFI-UHFFFAOYSA-N

物化性质

• 沸点：
  370.3±35.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Boc-溴乙胺 、 (6-hydroxy-1,2,3,4-tetrahydro-napthalen-2-yl)-acetic acid ethyl ester 生成 [6-(2-Tertbutoxycarbonylamino-ethoxy)-1,2,3,4-tetrahydro-napthalen-2-yl]-acetic Acid Ethyl Ester
  参考文献：
  名称：

  Bicyclic antagonists selective for the alphavbeta3 integrin

  摘要：

  这项发明提供了公式（I）的新型双环化合物：其中u、v、m、Y、G、A-B、R1、R1a、R2、R4、R5、R5a和R5b在规范中有定义，这些化合物表现出抑制骨吸收的活性，以及公式（II）的化合物：其中u、v、m、Y、G、D、A-B、R1、R1a、R2、R3、R4、R5、R5a和R5b在规范中有定义，这些化合物也表现出抑制骨吸收的活性。

  公开号：

  US20030109523A1

文献信息

• Bicyclic antagonists selective for the &agr;v&bgr;3 integrin
  申请人：Wyeth

  公开号：US06429214B1

  公开（公告）日：2002-08-06

  This invention provides novel bicyclic compounds of Formula (I): wherein u, v, m, Y, G, A—B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II) wherein u, v, m, Y, G, D, A—B, R1, R1a, R2, R3, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption.

  本发明提供了式(I)的新型双环化合物：其中u、v、m、Y、G、A—B、R1、R1a、R2、R4、R5、R5a和R5b在说明书中有定义，这些化合物表现出抑制骨吸收的活性，以及式(II)的化合物，其中u、v、m、Y、G、D、A—B、R1、R1a、R2、R3、R4、R5、R5a和R5b在说明书中有定义，这些化合物表现出抑制骨吸收的活性。
• BICYCLIC ANTAGONISTS SELECTIVE FOR THE(ALPHA)V(BETA)3 INTEGRIN
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP1198231A1

  公开（公告）日：2002-04-24
• US6429214B1
  申请人：——

  公开号：US6429214B1

  公开（公告）日：2002-08-06
• [EN] BICYCLIC ANTAGONISTS SELECTIVE FOR THE alpha v beta 3 INTEGRIN<br/>[FR] ANTAGONISTES BICYCLIQUES SELECTIFS CONTRE L'INTEGRINE DOLLAR G(A)V DOLLAR G(B)3
  申请人：AMERICAN HOME PROD

  公开号：WO2001007036A1

  公开（公告）日：2001-02-01

  This invention provides novel bicyclic compounds of Formula (I): wherein u, v, m, Y, G, A-B, R?1, R1a, R2, R4, R5, R5a, and R5b¿ are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II) wherein u, v, m, Y, G, D, A-B, R?1, R1a, R2, R3, R4, R5, R5a, and R5b¿ are defined in the specification which compounds exhibit activity as inhibitors of bone resorption.
• Bicyclic antagonists selective for the alphavbeta3 integrin
  申请人：Wyeth

  公开号：US20030109523A1

  公开（公告）日：2003-06-12

  This invention provides novel bicyclic compounds of Formula (I): 1 wherein u, v, m, Y, G, A-B, R 1 , R 1a , R 2 , R 4 , R 5 , R 5a , and R 5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II) 2 wherein u, v, m, Y, G, D, A-B, R 1 , R 1a , R 2 , R 3 R 4 , R 5 , R 5a , and R 5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption.

  这项发明提供了公式（I）的新型双环化合物：其中u、v、m、Y、G、A-B、R1、R1a、R2、R4、R5、R5a和R5b在规范中有定义，这些化合物表现出抑制骨吸收的活性，以及公式（II）的化合物：其中u、v、m、Y、G、D、A-B、R1、R1a、R2、R3、R4、R5、R5a和R5b在规范中有定义，这些化合物也表现出抑制骨吸收的活性。