(cycloprop-2-ene-1,1-diyldimethanol) bis(tert-butyldiphenylsilylether) | 1263324-44-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (cycloprop-2-ene-1,1-diyldimethanol) bis(tert-butyldiphenylsilylether)
• 英文别名: ((cycloprop-2-ene-1,1-diylbis(methylene))bis(oxy))bis(tert-butyldiphenylsilane)；Tert-butyl-[[1-[[tert-butyl(diphenyl)silyl]oxymethyl]cycloprop-2-en-1-yl]methoxy]-diphenylsilane
• CAS: 1263324-44-2
• 化学式: C₃₇H₄₄O₂Si₂
• 分子量: 576.926
• InChiKey: COPABPXRQJXMMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (cycloprop-2-ene-1,1-diyldimethanol) bis(tert-butyldiphenylsilylether) 、 diethylzinc 在 双(乙腈)氯化钯(II) 、 zinc trifluoromethanesulfonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 水 作用下， 以 二氯甲烷 、 正己烷 为溶剂， 生成 (2-ethylcyclopropane-1,1-diyldimethanol)bis(tert-butyldiphenylsilylether)
  参考文献：
  名称：

  Enantioselective Palladium-Catalyzed Carbozincation of Cyclopropenes

  摘要：

  A highly enantioselective palladium-catalyzed carbozincation of cyclopropenes has been developed. The intermediate cyclopropylzinc species, after transmetalation with copper, were trapped with various electrophiles. This one-pot procedure furnished functionalizied cyclopropenes with excellent diastereo- and enantioselectivity.

  DOI：

  10.1021/ol1029904
• 作为产物：
  描述：

  dimethyl 1-(trimethylsilyl)cyclopropene-3,3-dicarboxylate 在 咪唑 、 四丁基氟化铵 、 二异丁基氢化铝 作用下， 以 四氢呋喃 为溶剂， 生成 (cycloprop-2-ene-1,1-diyldimethanol) bis(tert-butyldiphenylsilylether)
  参考文献：
  名称：

  Organocatalytic Carbonyl-Olefin Metathesis

  摘要：

  The development of a catalytic carbonyl-olefin metathesis strategy is reported, in the context of the ring-opening metathesis of cyclopropenes with aldehydes using a,simple hydrazine catalyst The key to this reaction is 4 conceptual blueprint for metathesis chemistry that forgoes the traditional reliance on [2 + 2] cycloaddition modes in favor of a [3 + 2] paradigm.

  DOI：

  10.1021/ja309650u

文献信息

• [EN] ORGANOCATALYTIC CARBONYL-OLEFIN AND OLEFIN-OLEFIN METATHESIS<br/>[FR] MÉTATHÈSE ORGANOCATALYTIQUE CARBONYLE-OLÉFINE ET OLÉFINE-OLÉFINE
  申请人：UNIV COLUMBIA

  公开号：WO2014022454A1

  公开（公告）日：2014-02-06

  The present invention provides, inter alia, organocatalytic carbonyl-olefin metathesis process. This process involves contacting a carbonyl-containing moiety with an olefin-containing moiety in the presence of a catalyst and under conditions sufficient to form a metathesis product with the proviso that the process takes place in the absence of photochemical promotion, stoichiometric amounts of transition metals, and Brnsted and Lewis acid catalysts. The present invention also provides an organocatalytic olefin-olefin metathesis process. This process involves contacting a first olefin-containing moiety with a second olefin-containing moiety in the presence of a catalyst and under conditions sufficient to form a metathesis product with the proviso that the process takes place in the absence of stoichiometric amounts of transition metals. Products made by the processes disclosed herein are also provided.

  本发明提供了有机催化羰基-烯烃交换反应过程。该过程涉及在催化剂存在下，通过将含羰基的基团与含烯烃的基团接触，并在足以形成交换产物的条件下进行反应，但需注意该过程在无光化学促进、化学计量量的过渡金属和布伦斯特酸以及路易斯酸催化剂的情况下进行。本发明还提供了有机催化烯烃-烯烃交换反应过程。该过程涉及在催化剂存在下，通过将第一含烯烃的基团与第二含烯烃的基团接触，并在足以形成交换产物的条件下进行反应，但需注意该过程在无化学计量量的过渡金属的情况下进行。本文所披露的过程制备的产物也被提供。
• Rhodium(III)-Catalyzed Enantioselective Benzamidation of Cyclopropenes
  作者：Andrey P. Antonchick、Herbert Waldmann、Saad Shaaban、Houhua Li、Christian Merten

  DOI：10.1055/s-0040-1706026

  日期：2021.7

  pharmaceuticals and therefore engaging targets for the development of new methods for their synthesis. Herein the synthesis of enantioenriched cyclopropylamines through catalytic enantioselective C–H functionalization using a chiral RhJasCp complex is reported. The reaction proceeds under mild conditions with high enantiocontrol. This reaction enables access to cyclopropylamines with three contiguous stereocenters

  环丙胺是在多种天然产物和药物中发现的特征性结构基序，因此成为开发其合成新方法的目标。本文报道了使用手性Rh Jas Cp配合物通过催化对映选择性CH官能化合成富含对映体的环丙胺。反应在高对映体控制的温和条件下进行。该反应使得能够获得具有源自相应的环丙烯的三个连续的立体中心的环丙胺。