cholestene-(5)-triyl-(3β.4β.7β)-tribenzoate | 2691-27-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholestene-(5)-triyl-(3β.4β.7β)-tribenzoate
• 英文别名: 3β,4β,7α-tris-benzoyloxy-cholest-5-ene；3β,4β,7α-Tris-benzoyloxy-cholest-5-en；Cholesten-(5)-triyl-(3β.4β.7α)-tribenzoat
• CAS: 2691-27-2
• 化学式: C₄₈H₅₈O₆
• 分子量: 730.985
• InChiKey: RIMLNOZZERJWLP-YASPYLRNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.92
• 重原子数：
  54.0
• 可旋转键数：
  11.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  78.9
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  (3R,4R)-17-(1,5-Dimethyl-hexyl)-3,4-dihydroxy-10,13-dimethyl-1,2,3,4,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-7-one 在 吡啶 、 aluminum isopropoxide 、 异丙醇 作用下， 生成 cholestene-(5)-triyl-(3β.4β.7β)-tribenzoate
  参考文献：
  名称：

  ▵⁵-Cholestene-3β,4β,7α-triol and the Inhibition of the Oxidation of Hydroxyl Groups by Vicinal Substituents

  摘要：

  DOI：

  10.1021/ja01167a119

文献信息

• Ultrastructural Localisation of Sialoadhesin (Siglec- 1) on Macrophages in Rodent Lymphoid Tissues
  作者：Inge L. Schadee-Eestermans、Elizabeth C.M. Hoefsmit、Marja Van De Ende、Paul R. Crocker、Timo K. Van Den Berg

  DOI：10.1016/s0171-2985(00)80036-4

  日期：2000.11

  In previous studies it has been demonstrated that sialoadhesin is a macrophage-restricted adhesion receptor for lymphocytes and myeloid cells. It is under normal circumstances expressed by subpopulations of macrophages in lymphoid and haemopoietic tissues. In this study different immunoelectronmicroscopical techniques are used to investigate the ultrastructural localisation of sialoadhesin within the lymph node and spleen of rodents. The results show that sialoadhesin is selectively expressed by a subset of macrophages in peripheral lymphoid tissues. Sialoadhesin was localised predominantly on the plasma membrane and in particular in areas of intimate contact with lymphocytes, thereby visualizing putative local interaction between these cells. Interestingly, sialoadhesin was also detected in intracellular vesicles that were apparently taken up by macrophages. These findings are consistent with the putative role of sialoadhesin in local cell-cell interactions in lymphoid tissues. Surprisingly, sialoadhesin was also found at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells, suggesting that sialoadhesin also mediates interactions with these cell types.