4-butoxy-5,6,7,8-tetrahydro-[2]naphthoyl chloride | 875224-73-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-butoxy-5,6,7,8-tetrahydro-[2]naphthoyl chloride
• CAS: 875224-73-0
• 化学式: C₁₅H₁₉ClO₂
• 分子量: 266.768
• InChiKey: LEXQEATYCRYDQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N,N-二甲基乙醇胺 、 4-butoxy-5,6,7,8-tetrahydro-[2]naphthoyl chloride 生成 4-butoxy-5,6,7,8-tetrahydro-[2]naphthoic acid-(2-dimethylamino-ethyl ester); hydrochloride
  参考文献：
  名称：

  Posterior cruciate ligament reconstruction with the quadriceps tendon in chronic injuries

  摘要：

  We reviewed 18 patients (knees) operated on because of chronic PCL insufficiency. Preoperatively all the patients were severely disabled and showed a posterior drawer of 10 mm or more. A quadriceps tendon autograft was implanted using an open technique, direct posterior approach, and fixation to the tibia. A free semitendinosus graft was used to reconstruct the lateral collateral ligament in six knees and the medial collateral ligament in two. The patients were reviewed with a mean follow-up of 3.5 years (range 2-5.5) using the IKDC form. Stability was evaluated by stress radiography using the Telos de-ice. The mean side-to-side difference in posterior tibial displacement at 70degrees of knee flexion at follow-up was 4.8 mm; the side-to-side difference was less than 5 mm in 77% of cases. A side-to-side difference less than 2 mm in lateral joint line opening was found in five of six knees with a lateral collateral ligament reconstruction. Posterior tibial translation was similar in the knees with and those without collateral ligament reconstruction. Only one patient complained of significant pain and giving-way at follow-up. Patellofemoral crepitation was present in nine knees at follow-up although it was symptomatic only in one. The results of this series suggest that posterior cruciate ligament reconstruction using an autologous quadriceps tendon is a valuable option to reconstruct these severe injuries.

  DOI：

  10.1007/s00167-002-0288-9
• 作为产物：
  描述：

  5,6,7,8-tetrahydro-1-hydroxy-3-naphthoic acid 在 盐酸 、 氢氧化钾 、 氯化亚砜 、 硫酸 、 potassium carbonate 、 丁酮 作用下， 生成 4-butoxy-5,6,7,8-tetrahydro-[2]naphthoyl chloride
  参考文献：
  名称：

  Posterior cruciate ligament reconstruction with the quadriceps tendon in chronic injuries

  摘要：

  We reviewed 18 patients (knees) operated on because of chronic PCL insufficiency. Preoperatively all the patients were severely disabled and showed a posterior drawer of 10 mm or more. A quadriceps tendon autograft was implanted using an open technique, direct posterior approach, and fixation to the tibia. A free semitendinosus graft was used to reconstruct the lateral collateral ligament in six knees and the medial collateral ligament in two. The patients were reviewed with a mean follow-up of 3.5 years (range 2-5.5) using the IKDC form. Stability was evaluated by stress radiography using the Telos de-ice. The mean side-to-side difference in posterior tibial displacement at 70degrees of knee flexion at follow-up was 4.8 mm; the side-to-side difference was less than 5 mm in 77% of cases. A side-to-side difference less than 2 mm in lateral joint line opening was found in five of six knees with a lateral collateral ligament reconstruction. Posterior tibial translation was similar in the knees with and those without collateral ligament reconstruction. Only one patient complained of significant pain and giving-way at follow-up. Patellofemoral crepitation was present in nine knees at follow-up although it was symptomatic only in one. The results of this series suggest that posterior cruciate ligament reconstruction using an autologous quadriceps tendon is a valuable option to reconstruct these severe injuries.

  DOI：

  10.1007/s00167-002-0288-9