4-碘-N-[1-(苯基甲基)哌啶-4-基]苯甲酰胺 | 155798-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-碘-N-[1-(苯基甲基)哌啶-4-基]苯甲酰胺
• 英文名称: N-(N-benzylpiperidin-4-yl)-4-iodobenzamide
• 英文别名: 4-IBP；N-(1-benzylpiperidin-4-yl)-4-iodobenzamide
• CAS: 155798-12-2
• 化学式: C₁₉H₂₁IN₂O
• mdl: MFCD00673910
• 分子量: 420.293
• InChiKey: HELCSESNNDZLFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.315
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-碘苯甲酸 在 氯化亚砜 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 生成 4-碘-N-[1-(苯基甲基)哌啶-4-基]苯甲酰胺
  参考文献：
  名称：

  [125I] -N-（N-苄基哌啶-4-基）-4-碘苯甲酰胺的合成和表征，一种新型的sigma受体放射性药物：与MCF-7乳腺肿瘤细胞的高亲和力结合。

  摘要：

  DOI：

  10.1021/jm00038a002

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Selective cellular targeting: multifunctional delivery vehicles, multifunctional prodrugs, use as antineoplastic drugs
  申请人：Drug Innovation & Design, Inc.

  公开号：US20030138432A1

  公开（公告）日：2003-07-24

  The present invention relates to the compositions, methods, and applications of a novel approach to selective cellular targeting. The purpose of this invention is to enable the selective delivery and/or selective activation of effector molecules to target cells for diagnostic or therapeutic purposes. The present invention relates to multi-functional prodrugs or targeting vehicles wherein each functionality is capable of enhancing targeting selectivity, affinity, intracellular transport, activation or detoxification. The present invention also relates to ultra-low dose, multiple target, multiple drug chemotherapy and targeted immunotherapy for cancer treatment.

  本发明涉及一种新的选择性细胞靶向的组合物、方法和应用。本发明的目的是为了实现对目标细胞的选择性输送和/或选择性激活效应分子，以进行诊断或治疗。本发明涉及多功能前药或靶向载体，其中每个功能都能增强靶向选择性、亲和力、细胞内转运、激活或解毒。本发明还涉及超低剂量、多靶点、多药物化疗和靶向免疫疗法，用于癌症治疗。
• Compounds for cancer imaging and therapy
  申请人：RESEARCH CORPORATION TECHNOLOGIES, INC.

  公开号：US20010006619A1

  公开（公告）日：2001-07-05

  The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas, malignant melanomas, gliomas, neuroblastomas and pheochromocytomas. The compounds of the present invention can also bind with high specificity to cell surface sigma receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The present invention provides such compounds as agents for diagnostic imaging and for detecting and treating tumors containing the cancer cells described above.

  本发明涉及一类具有亲和力的化合物，例如肺癌细胞、结肠癌细胞、肾癌细胞、前列腺癌细胞、乳腺癌细胞、恶性黑色素瘤细胞、胶质母细胞瘤、神经母细胞瘤和嗜铬细胞瘤等癌细胞。本发明的化合物还可以与细胞表面的西格玛受体高度特异性结合，因此可以用于对具有丰富西格玛受体细胞的任何组织进行诊断成像。本发明提供了这种化合物作为诊断成像和检测和治疗含有上述癌细胞的肿瘤的药剂。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Use of Sigma-1 receptor agonist compounds
  申请人：MTA TÁMOGATOTT KUTATÓCSOPORTOK IRODÁJA

  公开号：US10124006B2

  公开（公告）日：2018-11-13

  The present invention is directed to compositions and methods for the prevention, inhibition, and/or treatment of progressive fibrosis present in various fibroproliferative disorders. In particular, embodiments of the present invention relate to the use of Sigma-1 receptor agonists for use in the treatment or prevention of progressive fibrosis characterized by the overproliferation of ECM producing cells, e.g. myofibroblasts and by the excessive deposition of ECM components in a medical or disease condition. Preferred Sigma-1-receptor agonists are disclosed.

  本发明涉及用于预防、抑制和/或治疗各种纤维增生性疾病中出现的进行性纤维化的组合物和方法。特别是，本发明的实施方案涉及 Sigma-1 受体激动剂在治疗或预防进行性纤维化中的用途，进行性纤维化的特征是 ECM 生成细胞（如肌成纤维细胞）的过度增殖以及医疗或疾病条件下 ECM 成分的过度沉积。本文公开了优选的 Sigma-1 受体激动剂。