2,4-dibromo-N-pyridin-2-ylbutanamide | 247900-81-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,4-dibromo-N-pyridin-2-ylbutanamide
• CAS: 247900-81-8
• 化学式: C₉H₁₀Br₂N₂O
• 分子量: 321.999
• InChiKey: VKIGLLSEDLVUPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-dibromo-N-pyridin-2-ylbutanamide 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成 3-溴-1-(吡啶-2-基)吡咯烷-2-酮
  参考文献：
  名称：

  Enantioselective reactions of radicals at the α position of γ-lactams

  摘要：

  gamma-lactams derived from 2-aminopyridines undergo free radical reactions with allyltrimethylsilane in the presence of Lewis acids and chiral bisoxazolines. Products have been obtained with enantiomeric excesses as high as 99%. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01370-2
• 作为产物：
  描述：

  2-氨基吡啶 、 2,4-二溴丁酰溴 生成 2,4-dibromo-N-pyridin-2-ylbutanamide
  参考文献：
  名称：

  Enantioselective reactions of radicals at the α position of γ-lactams

  摘要：

  gamma-lactams derived from 2-aminopyridines undergo free radical reactions with allyltrimethylsilane in the presence of Lewis acids and chiral bisoxazolines. Products have been obtained with enantiomeric excesses as high as 99%. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01370-2

文献信息

• Enantioselective reactions of radicals at the α position of γ-lactams
  作者：Ned A. Porter、Hao Feng、Ivanka K. Kavrakova

  DOI：10.1016/s0040-4039(99)01370-2

  日期：1999.9

  gamma-lactams derived from 2-aminopyridines undergo free radical reactions with allyltrimethylsilane in the presence of Lewis acids and chiral bisoxazolines. Products have been obtained with enantiomeric excesses as high as 99%. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.