5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-deoxy-3'-C-styryl-5-methyluridine | 318246-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-deoxy-3'-C-styryl-5-methyluridine
• CAS: 318246-97-8
• 化学式: C₄₀H₄₀N₂O₇
• 分子量: 660.767
• InChiKey: WMCPXAGJYKIOMR-UMEIXMCQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.11
• 重原子数：
  49.0
• 可旋转键数：
  12.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101.01
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-deoxy-3'-C-styryl-5-methyluridine 在 sodium periodate 、 四氧化锇 、 sodium cyanoborohydride 、 溶剂黄146 、 三氯乙酸 作用下， 以 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 9.67h， 生成
  参考文献：
  名称：

  Synthesis of 2′‐Substituted MMI Linked Nucleosidic Dimers: An Optimization Study in Search of High Affinity Oligonucleotides for Use in Antisense Constructs

  摘要：

  The synthesis of a series of methylene(methylimino) (MMI) linked oligodeoxyribonucleotide dimers modified at the 2'-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, his 2'-OMe MMI dimer was selected for further studies based on its synthetic accessibility and the increased thermodynamic stability conferred upon oligonucleotides incorporating this modification.

  DOI：

  10.1081/ncn-120028337
• 作为产物：
  描述：

  DMT-2'-甲氧基-5-甲基尿苷 在 4-二甲氨基吡啶 、 1,1'-偶氮(氰基环己烷) 作用下， 以 二氯甲烷 、 氯苯 为溶剂， 反应 18.0h， 生成 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-deoxy-3'-C-styryl-5-methyluridine
  参考文献：
  名称：

  An Efficient Multigram Synthesis of Monomers for the Preparation of Novel Oligonucleotides Containing Isosteric Non-Phosphorous Backbones

  摘要：

  The facile preparation of two novel classes of nucleoside analogs for the inclusion as dimeric non-phosphorous containing subunits in chimeric backbones has been accomplished. The concise preparation of 3'-formylnucleosides and 5'-O-(N-methylhydroxylamino)-nucleosides is reported.

  DOI：

  10.1080/07328319708006242