1,2,3,4-Tetrahydro-8-methoxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one | 59456-04-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1,2,3,4-Tetrahydro-8-methoxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one
• 英文别名: 8-methoxy-3-(2-morpholin-4-ylethyl)-2,4-dihydro-1H-chromeno[3,4-c]pyridin-5-one
• CAS: 59456-04-1
• 化学式: C₁₉H₂₄N₂O₄
• 分子量: 344.411
• InChiKey: DGTUAMGEFQTWGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,2,3,4-tetrahydro-8-methoxy-5H-[3,4-c]pyridin-5-one 、 N-(2-氯乙基)吗啉盐酸盐 在 盐酸 、 三乙胺 作用下， 以 乙醇 为溶剂， 生成 1,2,3,4-Tetrahydro-8-methoxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one
  参考文献：
  名称：

  Substituted benzopyrano[3,4-c]pyridines

  摘要：

  本发明揭示了具有以下结构式的取代苯并吡喃[3,4-c]吡啶：##SPC1## 在上述结构式中，R.sub.1和R.sub.2分别为氢、羟基或1至6个碳原子的较低烷氧基；X为氧原子、硫原子、甲基基团或由氢、1至6个碳原子的较低烷基基团或1至6个碳原子的较低烷酰基基团取代的氮原子。本发明的化合物是通过在酸催化剂存在下将R.sub.1、R.sub.2-取代酚与3-羧乙氧基-4-哌啶酮反应制备的，得到中间体R.sub.1、R.sub.2-取代苯并吡喃[3,4-c]吡啶。通过用适当取代的烷基卤化物处理苯并吡喃[3,4-c]吡啶，可以获得N-氨基烷基苯并吡喃[3,4-c]吡啶。本发明的化合物可用作治疗支气管哮喘的支气管扩张剂。

  公开号：

  US03946008A1

文献信息

• Benzopyrano(3,4-C)pyridine bronchodilators
  申请人：Warner-Lambert Company

  公开号：US03961057A1

  公开（公告）日：1976-06-01

  Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1## In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

  披萨酱油是一种以番茄酱为基础的调味料，通常用于披萨上。它的配方可以包括番茄、大蒜、洋葱、香草和其他香料。披萨酱油可以买到现成的，也可以自己制作。
• Substituted benzopyrano [3,4-c]pyridines for the treatment of bronchial
  申请人：Warner-Lambert Company

  公开号：US03984546A1

  公开（公告）日：1976-10-05

  Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1## In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

  本发明揭示了具有以下结构式的取代苯并吡喃[3,4-c]吡啶：##SPC1## 在上述公式中，R.sub.1和R.sub.2是氢、羟基或1至6个碳原子的低级烷氧基；X是氧原子、硫原子、亚甲基或被氢、1至6个碳原子的低级烷基或1至6个碳原子的低级脂肪酰基取代的氮原子。本发明的化合物是通过在酸催化剂存在下将R.sub.1，R.sub.2-取代的苯酚与3-羧乙氧基-4-哌啶酮反应形成中间体R.sub.1，R.sub.2-取代的苯并吡喃[3,4-c]吡啶制备而成。通过用适当取代的烷基卤代物处理苯并吡喃[3,4-c]吡啶，可以获得N-氨基烷基苯并吡喃[3,4-c]吡啶。本发明的化合物可用作支气管扩张剂，用于治疗支气管哮喘。
• Substituted benzopyrano[3,4-c]pyridines and process for their preparation
  申请人：Warner-Lambert Company

  公开号：US04013671A1

  公开（公告）日：1977-03-22

  Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##STR1## In the above formula, R.sub.1 R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c] pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

  本发明揭示了具有以下结构式的取代苯并吡喃[3,4-c]吡啶：##STR1## 在上述公式中，R.sub.1 R.sub.2是氢、羟基或1至6个碳原子的低烷氧基；R.sub.3是氢或1至6个碳原子的低烷基；X是氧原子、硫原子、亚甲基或氮原子，被氢、1至6个碳原子的低烷基或1至6个碳原子的低烷酰基取代。本发明的化合物是通过在酸催化剂存在下将R.sub.1，R.sub.2-取代苯酚与3-羰基-4-哌啶酮反应，得到中间体R.sub.1，R.sub.2-取代苯并吡喃[3,4-c]吡啶而制备的。通过用适当取代的烷基卤代物处理苯并吡喃[3,4-c]吡啶，可以获得N-氨基烷基苯并吡喃[3,4-c]吡啶。本发明的化合物可用作支气管扩张剂，用于治疗支气管哮喘。
• US3946008A
  申请人：——

  公开号：US3946008A

  公开（公告）日：1976-03-23
• US3961057A
  申请人：——

  公开号：US3961057A

  公开（公告）日：1976-06-01