N-phenethylnaphthalen-2-amine | 63458-19-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-phenethylnaphthalen-2-amine
• 英文别名: N-(2-phenylethyl)naphthalen-2-amine
• CAS: 63458-19-5
• 化学式: C₁₈H₁₇N
• 分子量: 247.34
• InChiKey: OXBZBPCSIVUJRW-UHFFFAOYSA-N

物化性质

• 沸点：
  240-260 °C(Press: 7 Torr)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯-3-苯基丙酸 生成 N-phenethylnaphthalen-2-amine
  参考文献：
  名称：

  Kato, Nippon Nogeikagaku Kaishi, 1953, vol. 27, p. 655

  摘要：

  DOI：

文献信息

• Nickel-Catalyzed Amination of Aryl Phosphates through Cleaving Aryl C–O Bonds
  作者：Jin-Hua Huang、Lian-Ming Yang

  DOI：10.1021/ol201437g

  日期：2011.7.15

  amination of triaryl phosphates was achieved using a Ni(II)–(σ-Aryl) complex/NHC catalyst system in dioxane at 110 °C in the presence of NaH as base. Electron-neutral, -rich, and -deficient triaryl phosphates were coupled with a wider range of amine partners including cyclic and acyclic secondary amines, aliphatic primary amines, and anilines in good to excellent yields.

  磷酸三芳基酯的胺化反应是通过使用Ni（II）-（σ-芳基）络合物/ NHC催化剂体系在二恶烷中于110°C，以NaH为碱的情况下实现的。电子中性的，富含和缺乏的磷酸三芳基酯与多种胺伙伴（包括环状和非环状仲胺，脂族伯胺和苯胺）的偶联效果良好或优异。
• Mono/Dual Amination of Phenols with Amines in Water
  作者：Wanyi Liang、Feng Xie、Zhihai Yang、Zheng Zeng、Chuanjiang Xia、Yibiao Li、Zhongzhi Zhu、Xiuwen Chen

  DOI：10.1021/acs.orglett.0c02924

  日期：2020.11.6

  We herein describe a practical direct amination of phenols through a palladium-catalyzed hydrogen-transfer-mediated activation method to synthesize the secondary and tertiary amines. In this conversion, environmentally friendly water and inexpensive ammonium formate were used as solvent and reductant, respectively. A range of amines, including aliphatic amines, aniline, secondary amines, and diamines

  我们在本文中描述了通过钯催化的氢转移介导的活化方法对苯酚进行的实际直接胺化反应，以合成仲胺和叔胺。在这种转化中，分别将环保型水和廉价的甲酸铵用作溶剂和还原剂。多种胺，包括脂族胺，苯胺，仲胺和二胺，可以通过这种方法有效地偶联，以实现酚的单/双胺化和环化。这项研究不仅为合成仲和叔萘胺提供了绿色和温和的策略，而且扩大了有机化学中氯喹的合成。
• Iodine Anion Catalyzed Cross-Dehydrogenative Aromatization for Access to Aromatic Amines
  作者：Yan Shi、Cui Yi、Xiaoli Huang、Yuhai Tang、Jiao Jiao、Yang Li

  DOI：10.1021/acs.joc.3c00860

  日期：2023.7.7

  efficient iodine anion catalyzed cross-dehydrogenative aromatization of cyclohexenones with amines has been developed under metal-free conditions, which affords aromatic amines in good to excellent yields with a broad substrate scope. Meanwhile, this reaction provides a new method for the construction of C(sp2)–N bonds and also a new strategy for slow generation of oxidants or electrophiles via in situ

  在无金属条件下开发了一种高效的碘阴离子催化环己烯酮与胺的交叉脱氢芳构化反应，可以在广泛的底物范围内以良好至优异的产率提供芳香胺。同时，该反应为C(sp 2 )-N键的构建提供了新的方法，也为通过原位脱卤缓慢生成氧化剂或亲电试剂提供了新的策略。此外，该方案为手性 NOBIN 衍生物提供了快速、简洁的方法。
• Classification of the oncofetal fibronection level for the indication of diseases and other conditions
  申请人：ADEZA BIOMEDICAL CORPORATION

  公开号：EP2299275A2

  公开（公告）日：2011-03-23

  A method for classifying the level of oncofetal fibronectin in a sample comprises measuring the amount of an oncofetal fibronectin indicating molecule in a sample; comparing the amount of oncofetal fibronectin indicating molecule in the sample to two or more threshold levels derived from the source of the oncofetal fibronectin and classifying the amount of oncofetal fibronectin indicating molecule in the sample according to the highest threshold level that is less than or equal to amount of the oncofetal fibronectin indicating molecule in the sample. The lower threshold may be 50 ng/ml and the higher threshold may be 150 ng/ml. A kit comprises a fibronectin or oncofetal fibronectin binding partner, a non-specific binder, a solid support containing a non-specific binding surface or a sample collection device; and a system for classifying the subject with respect to multiple thresholds.

  一种对样品中胎盘上纤维连接蛋白水平进行分类的方法，包括测量样品中胎盘上纤维连接蛋白指示分子的量； 将样本中的胎盘上纤维连接蛋白指示分子的量与从胎盘上纤维连接蛋白来源中得出的两个或多个阈值水平进行比较，并根据小于或等于样本中胎盘上纤维连接蛋白指示分子的量的最高阈值水平对样本中的胎盘上纤维连接蛋白指示分子的量进行分类。较低阈值可为 50 纳克/毫升，较高阈值可为 150 纳克/毫升。试剂盒包括纤维连接蛋白或胎盘上纤维连接蛋白结合伴侣、非特异性粘合剂、含有非特异性结合表面的固体支持物或样品收集装置；以及根据多个阈值对受试者进行分类的系统。
• Methods for detecting oncofetal fibronectin
  申请人：Hussa Robert

  公开号：US20060024723A1

  公开（公告）日：2006-02-02

  Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health and disease status and to assess the risk of developing a disease or condition. Methods for detecting the presence of oncofetal fibronectin indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided. Methods and products for detection of oncofetal fibronection for selection of concepti are provided.

  提供了检测样品中胎盘上纤维连接蛋白指示分子的方法和产品。还提供了胎盘上纤维连接蛋白的成像方法。在本文提供的某些方法中，样品经试剂处理和/或与非特异性粘合剂接触。本发明提供了用于检测受试者以确定健康和疾病状态以及评估罹患疾病或病症风险的方法。还提供了通过免疫测定和质谱分析等多种方法检测胎盘上纤维连接蛋白指示分子存在的方法。此外，还提供了检测胎盘上纤维蛋白的方法和产品，用于选择受孕者。