2-(羟甲基)-3-呋喃甲酸 | 23268-37-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 中文名称: 2-(羟甲基)-3-呋喃甲酸
• 英文名称: 2-(hydroxymethyl)-3-furancarboxylic acid
• 英文别名: 2-(Hydroxymethyl)furan-3-carboxylic acid
• CAS: 23268-37-3
• 化学式: C₆H₆O₄
• 分子量: 142.111
• InChiKey: NPVYVNWONHWTPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(羟甲基)-3-呋喃甲酸 在 氯化亚砜 作用下， 反应 6.0h， 以3.5 g的产率得到2-(氯甲基)-3-糠酰氯
  参考文献：
  名称：

  Pevzner; Ignat'ev; Ionin, Russian Journal of General Chemistry, 1999, vol. 69, # 4, p. 551 - 556

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(乙酰氧基甲基)-3-呋喃甲酸乙酯 在 氢氧化钾 、 水 作用下， 反应 5.0h， 生成 2-(羟甲基)-3-呋喃甲酸
  参考文献：
  名称：

  Pevzner; Ignat'ev; Ionin, Russian Journal of General Chemistry, 1999, vol. 69, # 4, p. 551 - 556

  摘要：

  DOI：

文献信息

• METHOD TO CONVERT MONOSACCHARIDES TO 5-(HYDROXYMETHYL) FURFURAL (HMF) USING BIOMASS-DERIVED SOLVENTS
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20140107355A1

  公开（公告）日：2014-04-17

  Described is a process to produce hydroxymethyl furfural (HMF) from biomass-derived sugars. The process includes the steps of reacting a C5 and/or C6 sugar-containing reactant derived from biomass in a monophasic or biphasic reaction solution comprising water and a co-solvent. The co-solvent can be beta-, gamma-, and/or delta-lactones derived from biomass, tetrahydrofuran (THF) derived from biomass, and/or methyltetrahydrofuran (MTHF) derived from biomass. The reaction takes place in the presence of an acid catalyst and a dehydration catalyst for a time and under conditions such that at least a portion of glucose or fructose present in the reactant is converted to HMF.

  描述了一种从生物质衍生的糖产生羟甲基糠醛（HMF）的过程。该过程包括以下步骤：在包含水和共溶剂的单相或双相反应溶液中，将从生物质中衍生的C5和/或C6糖含量的反应物与酸催化剂和脱水催化剂一起反应，共溶剂可以是从生物质中衍生的β-、γ- 和/或δ-内酯、从生物质中衍生的四氢呋喃（THF）和/或从生物质中衍生的甲基四氢呋喃（MTHF）。在一定时间和条件下，在酸催化剂和脱水催化剂的存在下，使反应物中存在的葡萄糖或果糖的至少一部分转化为HMF。
• US8772515B2
  申请人：——

  公开号：US8772515B2

  公开（公告）日：2014-07-08
• US9617234B1
  申请人：——

  公开号：US9617234B1

  公开（公告）日：2017-04-11
• [EN] METHOD TO CONVERT MONOSACCHARIDES TO 5-(HYDROXYMETHYL) FURFURAL (HMF) USING BIOMASS-DERIVED SOLVENTS<br/>[FR] PROCÉDÉ POUR CONVERTIR DES MONOSACCHARIDES EN 5-(HYDROXYMÉTHYL)FURFURAL (HMF) UTILISANT DES SOLVANTS ISSUS DE BIOMASSE
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2014058859A2

  公开（公告）日：2014-04-17

  Described is a process to produce hydroxymethyl furfural (HMF) from biomass- derived sugars. The process includes the steps of reacting a C5 and/or C6 sugar- containing reactant derived from biomass in a monophasic or biphasic reaction solution comprising water and a co-solvent. The co-solvent can be beta-, gamma-, and/or delta- lactones derived from biomass, tetrahydrofuran (THF) derived from biomass, and/or methyltetrahydrofuran (MTHF) derived from biomass. The reaction takes place in the presence of an acid catalyst and a dehydration catalyst for a time and under conditions such that at least a portion of glucose or fructose present in the reactant is converted to HMF.
• [EN] METHOD TO PRODUCE FURANDICARBOXYLIC ACID (FDCA) FROM 5-HYDROXYMETHYLFURFURAL (HMF)<br/>[FR] PROCÉDÉ DE PRODUCTION D'ACIDE FURANDICARBOXYLIQUE (FDCA) À PARTIR DE 5-HYDROXYMÉTHYLFURFURAL (HMF)
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2017106591A1

  公开（公告）日：2017-06-22

  A process to produce furandicarboxylic acid (FDCA). The process includes the steps of reacting a C6 sugar-containing reactant in a reaction solution comprising a first organic solvent selected from the group consisting of beta-, gamma-, and delta- lactones, hydrofurans, hydropyrans, and combinations thereof, in the presence of an acid catalyst for a time and under conditions wherein at least a portion of the C6 sugar present in the reactant is converted to 5-(hydroxymethyl)furfural (HMF); oxidizing the HMF into FDCA with or without separating the HMF from the reaction solution; and extracting the FDCA by adding an aprotic organic solvent having a dipole moment of about 1.0 D or less to the reaction solution.