(3-chloro-butyl)-dimethyl-amine | 5546-46-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3-chloro-butyl)-dimethyl-amine
• 英文别名: (+/-)-3-Chlor-1-dimethylamino-butan；(3-Chlor-butyl)-dimethyl-amin；1-dimethylamino-3-chlorobutane；3-Chlorbutyl-N,N-dimethylamin；4-Dimethylamino-2-chlor-butan；3-chloro-N,N-dimethylbutan-1-amine
• CAS: 5546-46-3
• 化学式: C₆H₁₄ClN
• 分子量: 135.637
• InChiKey: AAAUVSWWQXTZAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-chloro-butyl)-dimethyl-amine 在 氨 、 水 、 铜 作用下， 生成 1,N³,N³-trimethyl-propanediyldiamine
  参考文献：
  名称：

  Mannich; Margotte, Chemische Berichte, 1935, vol. 68, p. 278

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 (3-chloro-butyl)-dimethyl-amine
  参考文献：
  名称：

  Babajan et al., Zhurnal Obshchei Khimii, 1959, vol. 29, p. 386,388;engl.Ausg.S.390,391

  摘要：

  DOI：

文献信息

• Pyrrolopyridinylpyrimidin-2-ylamine derivatives
  申请人：Wucherer-Plietker Margarita

  公开号：US20110218198A1

  公开（公告）日：2011-09-08

  Compounds of the formula I in which X, R 1 , R 2 , R 3 , R 4 and R 6 have the meanings indicated in Claim 1 , are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.

  公式I中X、R1、R2、R3、R4和R6具有权利要求书中指示的含义，是细胞增殖/细胞活力的抑制剂，可用于肿瘤的治疗。
• LUMINOGENIC AND FLUOROGENIC COMPOUNDS AND METHODS TO DETECT MOLECULES OR CONDITIONS
  申请人：Promega Corporation

  公开号：US20140154716A1

  公开（公告）日：2014-06-05

  A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.

  本发明提供了一种检测样本中至少一种分子存在或数量的方法，该方法采用了luciferin的衍生物或荧光团的衍生物。还提供了用于执行本发明方法的化合物和组合物。
• 3-Aminoindazole derivatives and process for preparation thereof
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0049779A1

  公开（公告）日：1982-04-21

  A compound of the formula (I): wherein W, is a hydrogen atom or a group wherein Y is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R, and R2 each independently is a hydrogen atom or a C1-6 alkyl group and R,, R2 and the adjacent nitrogen atom may form a C4-6 heterocyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; W2 is a hydrogen atom or a group wherein Z is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R3 and R4 each independently is a hydrogen atom or a C1-6 alkyl group and R3, R4 and the adjacent nitrogen atom may form a C4-6 hetercyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; when W, is a hydrogen atom, W2 is the group; and when W2 is a hydrogen atom, W, is the group; and the pharmaceutically acceptable acid addition salt thereof.

  式 (I) 的化合物： 其中 W，是氢原子或 其中 Y 是 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；R 和 R2 各自独立地是氢原子或 C1-6 烷基，且 R、R2 和相邻的氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； W2 是氢原子或 其中 Z 为 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；以及 R3 和 R4 各自独立地为氢原子或 C1-6 烷基，且 R3、R4 和相邻氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； 当 W 是氢原子时，W2 是 基团；以及 当 W2 是氢原子时，W, 是基团；及 基团；及其药学上可接受的酸加成盐。
• Indazole derivatives
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0090972A2

  公开（公告）日：1983-10-12

  A compound of the formula (I): wherein W, and W2 each independently is a hydrogen atom or a group wherein Y is a n-C1-6 alkvlene group or a n-C1-6 alkylene group having a C1-6 alkyl group substituent; and R, and R2 each independently is a hydrogen atom or a C1-5 alkyl group, and group in group may form a saturated heterocyclic ring selected from the group consisting of morphohno. pyrrolidino, piperidino, homopiperidino and piperazino groups. and the saturated heterocyclic ring except the morpholino group may have at least one C1-4 alkyl group, hydroxyl group or halogen atom as a substituent; Z, is a hydrogen atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, a C1-3 alkyl group or a methoxy group; Z2 is a hydrogen atom or an amino group; when W, and W2 are both hydrogen atoms, Z, is a hydroxyl group or an iodine atom and Z2 is hydrogen atom, or Z, and 22 are both amino groups; When Z, and 22 are both hydrogen atoms, the group in either W, or W2 is a morpholino group; when Z, is a chlorine atom, a hydroxyl group, an iodine atom, a methyl group or a methoxy group, Z2 is a hydrogen atom; when Z, is an amino group, Z2 is a hydrogen atom or an amino group; when Z, is a methyl group, a methoxy group or an amino group, Z, is in the 5-position; when Z, is an iodine atom, Z, is in the 5- or 7-position; and when Z, and Z2 are both amino groups. Z, and Z2 are in the 5- and 7-positions; and the physiologically acceptable acid addition salt thereof.

  式 (I) 的化合物： 其中 W和W2各自独立地为氢原子或基团，其中 其中 Y 是 n-C1-6 烯基或具有 C1-6 烷基取代基的 n-C1-6 烯基；以及 R 和 R2 各自独立地是氢原子或 C1-5 烷基，且 中的基团 除吗啉基外，饱和杂环可具有至少一个 C1-4 烷基、羟基或卤原子作为取代基； Z 是氢原子、氯原子、溴原子、碘原子、羟基、氨基、C1-3 烷基或甲氧基； Z2 是氢原子或氨基； 当 W 和 W2 都是氢原子时，Z 是羟基或碘原子，Z2 是氢原子，或 Z 和 22 都是氨基； 当 Z 和 22 均为氢原子时，则 当 Z 和 22 均为氢原子时，W 或 W2 中的基团为吗啉基； 当 Z 为氯原子、羟基、碘原子、甲基或甲氧基时，Z2 为氢原子； 当 Z 为氨基时，Z2 为氢原子或氨基； 当 Z 是甲基、甲氧基或氨基时，Z 在 5 位；当 Z 是碘原子时，Z 在 5 或 7 位；当 Z 和 Z2 都是氨基时。Z和Z2分别位于5和7位；及其生理学上可接受的酸加成盐。
• Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
  申请人：Promega Corporation

  公开号：EP2277872B1

  公开（公告）日：2016-03-23