octahydro-quinolizin-1-ol | 22525-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: octahydro-quinolizin-1-ol
• 英文别名: 1-(Hydroxy-cis-10H)-chinolizidin；1-Hydroxy-chinolizidin；1-Hydroxychinolizidin；Octahydro-2H-quinolizin-1-ol；2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-ol
• CAS: 22525-60-6
• 化学式: C₉H₁₇NO
• mdl: MFCD00598828
• 分子量: 155.24
• InChiKey: MTVNMVKUNMOINI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  octahydro-quinolizin-1-ol 、 1H-吲哚-3-羰酰氯 在 silica gel 、 乙醚 作用下， 以to afford the title compound (E11a) as a white solid, mp 230°-232° C.的产率得到Quinolizidin-1-ylindole-3-carboxylate
  参考文献：
  名称：

  Azabicyclic compounds as 5-HT4 receptor antagonists

  摘要：

  化合物的式子(I) ##STR1## 其中L为N或CR.sub.c，其中R.sub.c为氢，烷氧基，卤素，烷基或氰基; Q为NR.sub.1，CH.sub.2，O或S; R.sub.a为氢，卤素，烷基，氨基，硝基或烷氧基; R.sub.b为氢，卤素，烷基或烷氧基; R.sub.1为氢，烷基，烯基，芳基烷基，酰基或酰基烷基; R.sub.2为烷氧基; R.sub.3为氢，氯或氟; R.sub.4为氢，烷基，氨基（可选择性地被烷基，卤素，羟基或烷氧基替换），卤素或烷氧基; R.sub.5为氢，卤素，烷基，烷氧基，硝基，氨基或烷基硫醚; R.sub.6为氢，卤素，烷基，烷氧基或氨基; n为0，1，2，3或4; p和m独立地为0，1或2; R.sub.q为氢或C.sub.1-6是5-HT.sub.4受体拮抗剂。

  公开号：

  US05552398A1
• 作为产物：
  描述：

  octahydro-1H-quinolizin-1-one hydrochloride 在 sodium tetrahydroborate 、 乙醇 作用下， 生成 octahydro-quinolizin-1-ol
  参考文献：
  名称：

  [EN] TRANSTHYRETIN STABILIZING COMPOUNDS
  [FR] COMPOSÉS STABILISATEURS DE TRANSTHYRÉTINE

  摘要：

  Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or amyloid formation in the peripheral nerves, kidney, cardiac tissue, eye and CNS, and of treating a subject with peripheral TTR amyloidosis.

  公开号：

  WO2023009585A2
• 作为试剂：
  描述：

  hexahydro-quinolizin-1-one 、 硼氢化钠 、 methanol-dichloromethane 、 在 水 、 magnesium sulfate 、 octahydro-quinolizin-1-ol 、 silica gel 、 Dichloromethane methanol ammonium hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以It was isolated in the form of a white solid with a yield of 78%的产率得到octahydro-quinolizin-1-ol
  参考文献：
  名称：

  1,4-DISUBSTITUTED 1,2,3-TRIAZOLES, METHODS FOR PREPARING SAME, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF

  摘要：

  具有以下一般式（I）的化合物：其中，X为氮原子，Y为碳原子；或X为碳原子，Y为氮原子；Ar基为芳基或杂芳基；RN和RN′基，与它们所连接的碳原子一起，形成单环或双环氮杂环烷基。还描述了其药物可接受的盐，水合物或多态晶体结构，以及其外消旋体，对映异构体或对映体。

  公开号：

  US20140030191A1

文献信息

• SUBSTITUTED ARYL AND HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20180206495A1

  公开（公告）日：2018-07-26

  Substituted aryl- and heteroarylcarbonyl hydrazides The invention relates to substituted aryl- and heteroarylcarbonyl hydrazides of the general formula (I) or salts thereof where the radicals of the formula (I) are each as defined in the description for enhancing stress tolerance in plants to abiotic stress, and for enhancing plant growth and/or for increasing plant yield.

  该发明涉及通式（I）的取代芳基和杂芳基羰基肼或其盐，其中通式（I）的基团如描述中所定义，用于增强植物对非生物胁迫的耐受性，促进植物生长和/或增加植物产量。
• SUBSTITUTED HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20180206498A1

  公开（公告）日：2018-07-26

  The invention relates to substituted heteroaryl carboxylic acid hydrazides of general formula (I) or salts thereof, wherein the groups of formula (I) have the definitions stated in the description, for increasing the stress tolerance in plants with respect to abiotic stress, and also for strengthening plant growth and/or for increasing plant yield.

  该发明涉及通式（I）的取代杂环芳基羧酸腙或其盐，其中通式（I）中的基团具有描述中所述的定义，用于增加植物对非生物胁迫的耐受性，同时也用于增强植物生长和/或增加植物产量。
• SUBSTITUTED 3-HETEROARYLOXY-1H-PYRAZOLES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL ACTIVE SUBSTANCES
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20200181117A1

  公开（公告）日：2020-06-11

  A substituted 3-heteroaryloxy-1H-pyrazole of the general formula (I) or salt thereof Substituted 3-heteroaryloxy-1H-pyrazoles of the general formula (I) are described, as is their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants described. The present invention also relates to herbicidal and/or plant growth-regulating compositions comprising one or more compounds of the general formula (I).

  通用式（I）的取代3-杂环氧基-1H-吡唑或其盐已被描述。 通用式（I）的取代3-杂环氧基-1H-吡唑被描述， 以及它们作为除草剂的用途，特别是用于控制作物中的阔叶杂草和/或杂草草，以及作为植物生长调节剂，影响作物生长的用途。 本发明还涉及包含一个或多个通用式（I）化合物的除草剂和/或植物生长调节剂组合物。
• SUBSTITUTED CYANO CYCLOALKYL PENTA-2,4-DIENES, CYANO CYCLOALKYL PENT-2-EN-4-YNES, CYANO HETEROCYCLYL PENTA-2,4-DIENES AND CYANO HETEROCYCLYL PENT-2-EN-4-YNES AS ACTIVE SUBSTANCES
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20170210701A1

  公开（公告）日：2017-07-27

  The invention relates to cyano cycloalkyl penta-2,4-dienes, cyano cycloalkyl pent-2-en-4-ynes, cyano heterocyclyl penta-2,4-dienes and cyano heterocyclyl pent-2-en-4-ynes of general formula (I), or the salts thereof, where [X-Y], Q, R 1 , R 2 , A 1 , A 2 , V, W, m and n have the definitions specified in the description. The invention also relates to a production method for same and to the use of same for increasing stress tolerance in plants against abiotic stress, and/or for increasing the plant yield.

  该发明涉及一般式(I)的氰基环烷基戊二烯、氰基环烷基戊-2-炔、氰基杂环烷基戊二烯和氰基杂环烷基戊-2-炔，或其盐，其中[X-Y]、Q、R1、R2、A1、A2、V、W、m和n的定义如描述中所指定。该发明还涉及同类物质的生产方法以及将其用于增加植物对非生物胁迫的抗逆性和/或增加植物产量。
• SUBSTITUTED AZOLYLPYRROLONES AND AZOLYLHYDANTOINS AND SALTS THEREOF AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20190330192A1

  公开（公告）日：2019-10-31

  The invention relates to substituted azolylpyrrolones and azolylhydantoines of general formula (I) and salts thereof, wherein the groups of general formula (I) are defined as cited in the description, and to the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.

  该发明涉及通式（I）所示的取代的氮杂环丙酮酮和氮杂环异噁唑酮，以及它们的盐，其中通式（I）中的基团如描述中所述定义，并且将其用作除草剂，特别是用于控制作物中的杂草和/或杂草，或者作为植物生长调节剂，用于影响作物的生长。