2-去氢金雀花碱 | 67528-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 中文名称: 2-去氢金雀花碱
• 英文名称: dehydrosparteine
• 英文别名: (7S)-(7ac,14at)-1,3,4,7,7a,8,9,13,14,14a-decahydro-2H,6H-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diazocine；(7S)-(7ac,14at)-1,3,4,7,7a,8,9,13,14,14a-Decahydro-2H,6H-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diazocin；2,3-Didehydrosparteine；(1S,2R,9S,10S)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadec-5-ene
• CAS: 67528-17-0
• 化学式: C₁₅H₂₄N₂
• 分子量: 232.369
• InChiKey: BWKNRAAXVUYXAH-XQLPTFJDSA-N

物化性质

• 沸点：
  110 °C(Press: 0.1 Torr)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-去氢金雀花碱 、 高氯酸 生成 (1S,2R,9S,10S)-15-aza-7-azoniatetracyclo[7.7.1.02,7.010,15]heptadec-6-ene;perchlorate
  参考文献：
  名称：

  EBNER, THOMAS;LACKNER, HELMUT;REMBERG, GERD;MEESE, CLAUS O., LIEBIGS ANN. CHEM.,(1989) N, C. 197-201

  摘要：

  DOI：
• 作为产物：
  描述：

  羽扇豆鹼 生成 2-去氢金雀花碱
  参考文献：
  名称：

  EBNER, THOMAS;LACKNER, HELMUT;REMBERG, GERD;MEESE, CLAUS O., LIEBIGS ANN. CHEM.,(1989) N, C. 197-201

  摘要：

  DOI：

文献信息

• Polymorphisms in the human gene for CYP2D6 and their use in diagnostic and therapeutic applications
  申请人：Raimundo Sebastian

  公开号：US20050032070A1

  公开（公告）日：2005-02-10

  The present invention relates to means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the CYP2D6 gene. In particular, the present invention relates to polynucleotides of molecular variants of the CYP2D6 gene, which for example, are associated with abnormal drug response and disorders caused by altered activity of the CYP2D6 enzyme, and vectors comprising these polynucleotides. Furthermore, the present invention relates to host cells comprising such polynucleotides or vectors. The invention also relates to a transgenic non-human animal. Furthermore, kits comprising oligonucleotides hybridizing to the CYP2D6 gene useful for the diagnosis of an altered activity of the CYP2D6 enzyme are provided. In addition, the invention relates to methods for diagnosing a polynucleotide associated with an intermediate metabolizer phenotype of CYP2D6 drugs.

  本发明涉及诊断和治疗 CYP2D6 基因几种遗传性异常表达和/或功能的表型谱以及重叠临床特征的手段和方法。特别是，本发明涉及 CYP2D6 基因分子变体的多核苷酸，例如，与 CYP2D6 酶活性改变引起的药物反应异常和疾病相关的多核苷酸，以及包含这些多核苷酸的载体。此外，本发明还涉及包含这些多核苷酸或载体的宿主细胞。本发明还涉及转基因非人类动物。此外，本发明还提供了包含与 CYP2D6 基因杂交的寡核苷酸的试剂盒，可用于诊断 CYP2D6 酶活性的改变。此外，本发明还涉及诊断与 CYP2D6 药物中间代谢物表型相关的多核苷酸的方法。
• Bohlmann, Chemische Berichte, 1958, vol. 91, p. 2157,2166
  作者：Bohlmann

  DOI：——

  日期：——
• EBNER, THOMAS;EICHELBAUM, MICHEL;FISCHER, PETER;MEESE, CLAUS O., ARCH. PHARM., 322,(1989) N, C. 399-403
  作者：EBNER, THOMAS、EICHELBAUM, MICHEL、FISCHER, PETER、MEESE, CLAUS O.

  DOI：——

  日期：——
• POLYMORPHISMS IN THE HUMAN CYP2D6 GENE PROMOTER REGION AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
  申请人：Epidauros Biotechnologie AG

  公开号：EP1276880B1

  公开（公告）日：2006-07-19
• Polymorphisms in the human cyp2d6 gene promoter region and their use in diagnostic and therapeutic applications
  申请人：——

  公开号：US20040224424A1

  公开（公告）日：2004-11-11

  Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vectors comprising such polynucleotides. Furthermore, methods of diagnosing the status of disorders related to intermediate metabolization of drugs are described. In addition, kits comprising oligonucleotides hybridizing to the CYP2D6 promoter and/or being capable of being extended into this region useful for diagnosing subjects that are ultrarapid or intermediate metabolizer of drugs are provided.