10-[(1,4-dihydro-1,4-dioxonaphthalen-3-yl)amino]decyl methanesulfonate | 1374028-58-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 10-[(1,4-dihydro-1,4-dioxonaphthalen-3-yl)amino]decyl methanesulfonate
• 英文别名: 10-[(1,4-Dioxonaphthalen-2-yl)amino]decyl methanesulfonate；10-[(1,4-dioxonaphthalen-2-yl)amino]decyl methanesulfonate
• CAS: 1374028-58-6
• 化学式: C₂₁H₂₉NO₅S
• 分子量: 407.531
• InChiKey: PECXPMLSSLSIEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  10-[(1,4-dihydro-1,4-dioxonaphthalen-3-yl)amino]decyl methanesulfonate 、 三苯基膦 反应 0.5h， 生成 (10-((1,4-dihydro-1,4-dioxonaphthalen-3-yl)amino)decyl)triphenylphosphonium methanesulfonate
  参考文献：
  名称：

  Phosphonium lipocations as antiparasitic agents

  摘要：

  Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low mu M concentrations against T. cruzi. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2012.02.045
• 作为产物：
  描述：

  10-氨基-1-癸醇 在 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 10-[(1,4-dihydro-1,4-dioxonaphthalen-3-yl)amino]decyl methanesulfonate
  参考文献：
  名称：

  Phosphonium lipocations as antiparasitic agents

  摘要：

  Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low mu M concentrations against T. cruzi. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2012.02.045

文献信息

• [EN] SMALL MOLECULE NAPHTHOQUINONE- AND PHTHALIMIDE-BASED LIPOCATIONS AS ANTI-PARASITIC AGENTS<br/>[FR] LIPOCATIONS À BASE DE NAPHTOQUINONE ET DE PHTALIMIDE À PETITES MOLÉCULES EN TANT QU'AGENTS ANTI-PARASITAIRES
  申请人：UNIV GEORGIA

  公开号：WO2013036766A1

  公开（公告）日：2013-03-14

  Small molecule naphthoquinone- and phthalimide-based lipocations are provided, as well as methods for their use in treating or preventing anti-parasitic diseases, such as malaria, Chagas disease, and African Sleeping Sickness.

  提供了基于小分子萘醌和邻苯二酰亚胺的脂质载体，以及它们在治疗或预防抗寄生虫疾病（如疟疾、克氏病和非洲睡眠病）中的使用方法。
• Phosphonium lipocations as antiparasitic agents
  作者：Timothy E. Long、Xiao Lu、Melina Galizzi、Roberto Docampo、Jiri Gut、Philip J. Rosenthal

  DOI：10.1016/j.bmcl.2012.02.045

  日期：2012.4

  Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low mu M concentrations against T. cruzi. Published by Elsevier Ltd.