N-Pentyl-2-mercapto-ethylamin | 89979-93-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Pentyl-2-mercapto-ethylamin
• 英文别名: 2-(Pentylamino)ethanethiol
• CAS: 89979-93-1
• 化学式: C₇H₁₇NS
• mdl: MFCD19222757
• 分子量: 147.285
• InChiKey: JOLTUZIGEBWOKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  13
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-丁基-1,3-噻唑烷 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N-Pentyl-2-mercapto-ethylamin
  参考文献：
  名称：

  Eliel,E.L. et al., Journal of Organic Chemistry, 1962, vol. 27, p. 4712 - 4713

  摘要：

  DOI：

文献信息

• Sixteen-membered macrolide compounds
  申请人：——

  公开号：US20020111317A1

  公开（公告）日：2002-08-15

  The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and methods and formulations for their use. In one aspect of the present invention, sixteen-membered macrolide possessing a side chain Z are provided where Z is aliphatic, aryl, alkylaryl, halide, ═NOR 3 , ═NNHR 3 , or —W—R 3 where W is O, S, NC(═O)R 4 , NC(═O)OR 4 , NC(═O)NHR 4 or NR 4 where R 3 and R 4 are each independently hydrogen, aliphatic, aryl or alkylaryl. In another aspect of the present invention, bicyclic compounds are provided where one of the cyclic-components is a sixteen-membered macrolide and the other is a cyclic moiety whose cyclic structure is formed by between 3 and 10 atoms. In another aspect of the present invention, sixteen-membered macrolide compounds that bind to the domain II region of the 23S RNA are provided.

  本发明提供了新型的十六元大环内酯化合物，可用作抗感染药物或其中间体。本发明还提供了制备这些化合物的方法，以及它们的使用方法和配方。在本发明的一个方面，提供了具有侧链Z的十六元大环内酯，其中Z是脂肪族、芳香族、烷基芳基、卤素、═NOR3、═NNHR3或—W—R3，其中W为O、S、NC(═O)R4、NC(═O)OR4、NC(═O)NHR4或NR4，其中R3和R4各自独立地为氢、脂肪族、芳香族或烷基芳基。在本发明的另一个方面，提供了双环化合物，其中一个环组分是十六元大环内酯，另一个是由3至10个原子形成的环状基团。在本发明的另一个方面，提供了与23S RNA的II区域结合的十六元大环内酯化合物。
• JPH04352712A
  申请人：——

  公开号：JPH04352712A

  公开（公告）日：1992-12-07
• DIRECT SOLID SAMPLE ANALYTICAL TECHNOLOGY FOR DETERMINING A CONTENT AND A UNIFORMITY THEREOF IN A LYOPHILIZED KIT OF A SULFUR-CONTAINING CHELATOR WITH A STABLE COMPLEX CAPACITY FOR RADIOTECHNETIUM (TC-99M) AND RADIORHENIUM (RE-186, RE-188)
  申请人：LIU KUNG-TIEN

  公开号：US20120101741A1

  公开（公告）日：2012-04-26

  The present invention is related to a direct solid sample analytical technology for determining a content and a uniformity thereof in a lyophilized kit of a sulfur-containing chelator with a stable complex capacity for radiotechnetium (Tc-99m) and radiorhenium (Re-186, Re-188). An economical, stable and easily accessible coal standard is used herein as a contrast substance to construct a sulfur calibration curve, followed by obtaining the sulfur content and the uniformity thereof in the solid lyophilized sample by interpolating the foregoing result into the sulfur calibration curve. Then, the weight content percent is converted to get the content and the uniformity of the chelator in the lyophilized kit. The quality control of active pharmaceutical ingredients (API) in the lyophilized kit during key production processes and clinical applications is thus assured.
• US5225191A
  申请人：——

  公开号：US5225191A

  公开（公告）日：1993-07-06
• [EN] SIXTEEN-MEMBERED MACROLIDE COMPOUNDS<br/>[FR] COMPOSES MACROLIDES A SEIZE ELEMENTS
  申请人：KOSAN BIOSCIENCES INC

  公开号：WO2002032916A2

  公开（公告）日：2002-04-25

  The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and methods and formulations for their use. In one aspect of the present invention, sixteen-membered macrolide possessing a side chain Z are provided where Z is aliphatic, aryl, alkylaryl, halide, =NOR?3, =NNHR3¿, or -W-R3 where W is O, S, NC(=O)R4, NC(=O)OR4, NC(=O)NHR?4 or NR4¿ where R?3 and R4¿ are each independently hydrogen, aliphatic, aryl or alkylaryl. In another aspect of the present invention, bicyclic compounds are provided where one of the cyclic-components is a sixteen-membered macrolide and the other is a cyclic moiety whose cyclic structure is formed by between 3 and 10 atoms. In another aspect of the present invention, sixteen-membered macrolide compounds that bind to the domain II region of the 23S RNA are provided.